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Extensive horizontal gene transfers between plant pathogenic fungi

Overview of attention for article published in BMC Biology, May 2016
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Title
Extensive horizontal gene transfers between plant pathogenic fungi
Published in
BMC Biology, May 2016
DOI 10.1186/s12915-016-0264-3
Pubmed ID
Authors

Huan Qiu, Guohong Cai, Jing Luo, Debashish Bhattacharya, Ning Zhang

Abstract

Horizontal gene transfer (HGT) plays an important role in the adaptation of lineages to changing environments. The extent of this process in eukaryotes, however, remains controversial. The most well-known and dramatic form of HGT represents intracellular gene transfer from endosymbionts to the host nuclear genome. Such episodes of transfer typically involve hundreds of genes and are thought to be possible only in the case of endosymbiosis. Using a conservative phylogenomic approach, we analyzed genomic data from the fungal pathogen Magnaporthiopsis incrustans in the order Magnaporthales and identified two instances of exclusive sharing of HGT-derived gene markers between Magnaporthales and another lineage of plant-pathogenic fungi in the genus Colletotrichum. Surprisingly, inspection of these data demonstrated that HGT is far more widespread than anticipated, with more than 90 genes (including 33 highly supported candidates) being putatively transferred between Magnaporthales and Colletotrichum. These gene transfers are often physically linked in the genome and show more than two-fold functional enrichment in carbohydrate activating enzymes associated with plant cell wall degradation. Our work provides a novel perspective on the scale of HGT between eukaryotes. These results challenge the notion that recognized HGT plays a minor role in the evolution of fungal lineages, and in the case we describe, is likely implicated in the evolution of plant pathogenesis. More generally, we suggest that the expanding database of closely related eukaryotic genomes and the application of novel analytic methods will further underline the significant impact of foreign gene acquisition across the tree of life. Major lifestyle transitions such as those accompanying the origin of extremophily or pathogenesis are expected to be ideal candidates for studying the mode and tempo of HGT.

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Geographical breakdown

Country Count As %
United States 1 <1%
Brazil 1 <1%
Unknown 114 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 29 25%
Researcher 23 20%
Student > Master 14 12%
Student > Bachelor 11 9%
Student > Postgraduate 7 6%
Other 13 11%
Unknown 19 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 44 38%
Biochemistry, Genetics and Molecular Biology 33 28%
Immunology and Microbiology 4 3%
Chemistry 3 3%
Environmental Science 2 2%
Other 7 6%
Unknown 23 20%