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The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria

Overview of attention for article published in Malaria Journal, March 2011
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Mentioned by

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2 tweeters
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2 Facebook pages

Citations

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33 Dimensions

Readers on

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102 Mendeley
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Title
The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria
Published in
Malaria Journal, March 2011
DOI 10.1186/1475-2875-10-s1-s10
Pubmed ID
Authors

Patrice N Mimche, Donatella Taramelli, Livia Vivas

Abstract

The clinical manifestations of cerebral malaria (CM) are well correlated with underlying major pathophysiological events occurring during an acute malaria infection, the most important of which, is the adherence of parasitized erythrocytes to endothelial cells ultimately leading to sequestration and obstruction of brain capillaries. The consequent reduction in blood flow, leads to cerebral hypoxia, localized inflammation and release of neurotoxic molecules and inflammatory cytokines by the endothelium. The pharmacological regulation of these immunopathological processes by immunomodulatory molecules may potentially benefit the management of this severe complication. Adjunctive therapy of CM patients with an appropriate immunomodulatory compound possessing even moderate anti-malarial activity with the capacity to down regulate excess production of proinflammatory cytokines and expression of adhesion molecules, could potentially reverse cytoadherence, improve survival and prevent neurological sequelae. Current major drug discovery programmes are mainly focused on novel parasite targets and mechanisms of action. However, the discovery of compounds targeting the host remains a largely unexplored but attractive area of drug discovery research for the treatment of CM. This review discusses the properties of the plant immune-modifier curcumin and its potential as an adjunctive therapy for the management of this complication.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
Brazil 1 <1%
Pakistan 1 <1%
India 1 <1%
Switzerland 1 <1%
United States 1 <1%
Unknown 95 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 25%
Student > Bachelor 14 14%
Lecturer 12 12%
Researcher 11 11%
Student > Master 10 10%
Other 24 24%
Unknown 5 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 31 30%
Medicine and Dentistry 20 20%
Chemistry 12 12%
Biochemistry, Genetics and Molecular Biology 10 10%
Pharmacology, Toxicology and Pharmaceutical Science 8 8%
Other 13 13%
Unknown 8 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2020.
All research outputs
#8,447,321
of 14,602,561 outputs
Outputs from Malaria Journal
#2,910
of 4,248 outputs
Outputs of similar age
#62,403
of 123,859 outputs
Outputs of similar age from Malaria Journal
#1
of 1 outputs
Altmetric has tracked 14,602,561 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,248 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 123,859 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them