@anshulkundaje @BioMickWatson That's a very good question. In an early paper (w/ @vntranos) we looked at clustering in the ambient space, and it works well. 1/ https://t.co/9PgyoVWrio
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@Ebony_rw @hippopedoid The question of what the appropriate metric to use in gene expression space (specifically for sparsely sampled single-cell RNA-seq data) is an excellent one, and I agree it's not clear what to use. We looked at this a bit here https:
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@LGMartelotto @KevinBlighe This reminds me of a time when we did care : ) Fig5 in https://t.co/AbeWmHJNO9 was about the correct classification of a single cell! https://t.co/yz4tGjjwDl
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@stephenfloor @davidvanvalen @CytoNology @rita_strack @gheimberg @HanaScientist There is also no citation of https://t.co/9PgyoWduko which explored the efficacy of clustering using subsampled reads. Not to mention Zhang, @vntranos and Tse's key paper on th