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Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: Effect of age and 12-week exercise training

Overview of attention for article published in GeroScience, June 2012
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Title
Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: Effect of age and 12-week exercise training
Published in
GeroScience, June 2012
DOI 10.1007/s11357-012-9414-x
Pubmed ID
Authors

Carissa J. Murrell, James D. Cotter, Kate N. Thomas, Samuel J. E. Lucas, Michael J. A. Williams, Philip N. Ainslie

Abstract

Chronic reductions in cerebral blood flow (CBF) and cerebrovascular reactivity to CO2 are risk factors for cerebrovascular disease. Higher aerobic fitness is associated with higher CBF at any age; however, whether CBF or reactivity can be elevated following an exercise training intervention in healthy individuals is unknown. The aim of this study was to assess the effect of exercise training on CBF and cerebrovascular reactivity at rest and during exercise in young and older individuals. Ten young (23 ± 5 years; body mass index (BMI), 26 ± 3 kg m(-2); [Formula: see text], 35 ± 5 ml kg(-1) min(-1)) and 10 older (63 ± 5 years; BMI, 25 ± 3.0 kg m(-2); [Formula: see text], 26 ± 4 ml kg(-1) min(-1)) previously sedentary individuals breathed 5 % CO2 for 3 min at rest and during steady-state cycling exercise (30 and 70 % heart rate range (HRR)) prior to and following a 12-week aerobic exercise intervention. Effects of training on middle cerebral artery blood velocity (MCAv) at rest were unclear in both age groups. The absolute MCAv response to exercise was greater in the young (9 and 9 cm s(-1) (30 and 70 % HRR, respectively) vs. 5 and 4 cm s(-1) (older), P < 0.05) and was similar following training. Cerebrovascular reactivity was elevated following the 12-week training at rest (2.87 ± 0.76 vs. 2.54 ± 1.12 cm s(-1) mm Hg(-1), P = 0.01) and during exercise, irrespective of age. The finding of a training-induced elevation in cerebrovascular reactivity provides further support for exercise as a preventative tool in cerebrovascular and neurological disease with ageing.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 199 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 2 1%
Japan 2 1%
United Kingdom 1 <1%
Canada 1 <1%
Poland 1 <1%
Unknown 192 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 35 18%
Student > Master 32 16%
Researcher 24 12%
Student > Bachelor 24 12%
Student > Postgraduate 12 6%
Other 37 19%
Unknown 35 18%
Readers by discipline Count As %
Medicine and Dentistry 43 22%
Sports and Recreations 31 16%
Agricultural and Biological Sciences 25 13%
Neuroscience 21 11%
Psychology 12 6%
Other 22 11%
Unknown 45 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2012.
All research outputs
#17,285,036
of 25,373,627 outputs
Outputs from GeroScience
#1,249
of 1,594 outputs
Outputs of similar age
#118,860
of 180,824 outputs
Outputs of similar age from GeroScience
#16
of 28 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,594 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.0. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 180,824 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.