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Comparison of biochemical and immunological profile of pediatric patients with acute myeloid leukemia in relation to healthy individuals

Overview of attention for article published in Jornal de Pediatria, September 2015
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Title
Comparison of biochemical and immunological profile of pediatric patients with acute myeloid leukemia in relation to healthy individuals
Published in
Jornal de Pediatria, September 2015
DOI 10.1016/j.jped.2014.12.004
Pubmed ID
Authors

Fabiane L.F.Z. Sanches, Taís M. Nitsch, Maria Marluce S. Vilela, Valdemiro C. Sgarbieri

Abstract

To compare the biochemical and immunological profiles of pediatric patients with acute myeloid leukemia (AML) with healthy children and adolescents. This was a cross-sectional study in which 21 therapy-naïve patients with AML were compared with a group of 24 healthy individuals. The following data were analyzed: serum proteins, leucocytes and subgroups, erythrocytes, hematocrit, hemoglobin, platelets, cytokines in peripheral blood mononuclear cells cultures under spontaneous and BCG- or PHA-stimulated conditions, immunoglobulin A, and erythrocytic glutathione. Statistical analysis was performed using SPSS software, considering as significant p-values<0.05. Serum albumin levels were higher (p<0.0001) in the control group, as well as all the parameters related to red blood cells (p<0.0001). For leucocytes and subgroups, no statistical difference was found between the AML and the control groups. For cytokines, the concentrations were significantly higher under spontaneous and BCG-stimulated conditions for TNF-α, IL-6, IL-10, and IFN-γ in the control group. Under PHA-stimulated conditions, the concentration was higher (p=0.002) only for IL-6. No difference was found between the two groups for the other cytokines and for IgA in the saliva. Erythrocytic glutathione was higher (p<0.0001) in AML patients. It was possible to characterize the biochemical and immunological profile of pediatric patients with AML, as well as highlight some significant differences in these parameters when comparing with healthy children and adolescents.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 40%
Student > Master 4 13%
Professor 3 10%
Other 2 7%
Researcher 2 7%
Other 3 10%
Unknown 4 13%
Readers by discipline Count As %
Medicine and Dentistry 8 27%
Agricultural and Biological Sciences 5 17%
Nursing and Health Professions 5 17%
Chemistry 2 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 3 10%
Unknown 6 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2016.
All research outputs
#11,161,693
of 12,546,249 outputs
Outputs from Jornal de Pediatria
#342
of 419 outputs
Outputs of similar age
#220,258
of 264,773 outputs
Outputs of similar age from Jornal de Pediatria
#6
of 6 outputs
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So far Altmetric has tracked 419 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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