Title |
Cancer of the ampulla of Vater: analysis of the whole genome sequence exposes a potential therapeutic vulnerability
|
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Published in |
Genome Medicine, July 2012
|
DOI | 10.1186/gm357 |
Pubmed ID | |
Authors |
Michael J Demeure, David W Craig, Shripad Sinari, Tracy M Moses, Alexis Christoforides, Jennifer Dinh, Tyler Izatt, Jessica Aldrich, Ardis Decker, Angela Baker, Irene Cherni, April Watanabe, Lawrence Koep, Douglas Lake, Galen Hostetter, Jeffrey M Trent, Daniel D Von Hoff, John D Carpten |
Abstract |
Recent advances in the treatment of cancer have focused on targeting genomic aberrations with selective therapeutic agents. In rare tumors, where large-scale clinical trials are daunting, this targeted genomic approach offers a new perspective and hope for improved treatments. Cancers of the ampulla of Vater are rare tumors that comprise only about 0.2% of gastrointestinal cancers. Consequently, they are often treated as either distal common bile duct or pancreatic cancers. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 8% |
Korea, Republic of | 1 | 4% |
Unknown | 21 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 29% |
Student > Ph. D. Student | 6 | 25% |
Other | 2 | 8% |
Student > Master | 2 | 8% |
Professor | 1 | 4% |
Other | 2 | 8% |
Unknown | 4 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 42% |
Biochemistry, Genetics and Molecular Biology | 4 | 17% |
Medicine and Dentistry | 3 | 13% |
Computer Science | 1 | 4% |
Psychology | 1 | 4% |
Other | 1 | 4% |
Unknown | 4 | 17% |