Title |
Multiple Targeting Approaches on Histamine H3 Receptor Antagonists
|
---|---|
Published in |
Frontiers in Neuroscience, May 2016
|
DOI | 10.3389/fnins.2016.00201 |
Pubmed ID | |
Authors |
Mohammad A. Khanfar, Anna Affini, Kiril Lutsenko, Katarina Nikolic, Stefania Butini, Holger Stark |
Abstract |
With the very recent market approval of pitolisant (Wakix®), the interest in clinical applications of novel multifunctional histamine H3 receptor antagonists has clearly increased. Since histamine H3 receptor antagonists in clinical development have been tested for a variety of different indications, the combination of pharmacological properties in one molecule for improved pharmacological effects and reduced unwanted side-effects is rationally based on the increasing knowledge on the complex neurotransmitter regulations. The polypharmacological approaches on histamine H3 receptor antagonists on different G-protein coupled receptors, transporters, enzymes as well as on NO-signaling mechanism are described, supported with some lead structures. |
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United States | 1 | 25% |
Chile | 1 | 25% |
Switzerland | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
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Unknown | 68 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 19 | 28% |
Student > Master | 12 | 18% |
Student > Bachelor | 10 | 15% |
Researcher | 6 | 9% |
Lecturer | 2 | 3% |
Other | 8 | 12% |
Unknown | 11 | 16% |
Readers by discipline | Count | As % |
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Chemistry | 16 | 24% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
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Nursing and Health Professions | 2 | 3% |
Other | 5 | 7% |
Unknown | 19 | 28% |