@HaHaGentherapie Het is letterlijk overal te vinden. Het maakt niet uit waar je kijkt. Voorbeelden te over. https://t.co/MAHXadQoH6 https://t.co/895jxuxutq
RT @michaelzlin: Another nitpick: most antigen is synthesized in myocytes after the intramuscular injection, not directly by antigen-presen…
RT @michaelzlin: Another nitpick: most antigen is synthesized in myocytes after the intramuscular injection, not directly by antigen-presen…
RT @michaelzlin: Another nitpick: most antigen is synthesized in myocytes after the intramuscular injection, not directly by antigen-presen…
Another nitpick: most antigen is synthesized in myocytes after the intramuscular injection, not directly by antigen-presenting cells https://t.co/JfQuk8nKSq https://t.co/qaXEUj8Jkm
@theraghav @Clarksterh @razibkhan @clairlemon which one? this paper finds length of dose interval does have an effect https://t.co/tvZLtC19md another possibility why AZ's chadox1 has longer lasting efficacy is prolonged production of spike proteins: http
RT @JSchmukler: Esta es una excelente review sobre las vacunas con vector adenoviral (como AZ, Janssen y Sputnik) https://t.co/age6Emgwb5
RT @JSchmukler: Esta es una excelente review sobre las vacunas con vector adenoviral (como AZ, Janssen y Sputnik) https://t.co/age6Emgwb5
RT @JSchmukler: Esta es una excelente review sobre las vacunas con vector adenoviral (como AZ, Janssen y Sputnik) https://t.co/age6Emgwb5
RT @JSchmukler: Esta es una excelente review sobre las vacunas con vector adenoviral (como AZ, Janssen y Sputnik) https://t.co/age6Emgwb5
Esta es una excelente review sobre las vacunas con vector adenoviral (como AZ, Janssen y Sputnik) https://t.co/age6Emgwb5
@eljesusargento estoy todavía releyéndolo. Más tarde hago un mini hilo. https://t.co/4iuAzZwnmN
*astrazeneca, though, so i expect that full immunity will take a little longer as it appears to be a slower burn vaccine than the mrna ones
i've been wondering why the AZ corona shot needs months to reach maximum effectiveness. answer is longer persistence of viral vector in cells. curious to see if this will be observed in the other vector utilizing vaccines.
RT @DevanSinha: @AntellPhilippa NYT overview of ChAdOx1 mechanism (source of pics): https://t.co/dwMI7SBLXc More detailed science papers…
Oder auch dies, eine echte Fundgrube für interessante und immer gut belegte Überlegungen/Einschätzungen. Lohnt sich: https://t.co/0ZgI2K1lnr
RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…
RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…
RT @DevanSinha: @AntellPhilippa NYT overview of ChAdOx1 mechanism (source of pics): https://t.co/dwMI7SBLXc More detailed science papers…
RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…
RT @fascinatorfun: We’re still in the fairly early stages of 2nd dose roll out of AZ (9-11 week interval would suggest starting maybe in th…
RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…
RT @fascinatorfun: We’re still in the fairly early stages of 2nd dose roll out of AZ (9-11 week interval would suggest starting maybe in th…
RT @fascinatorfun: We’re still in the fairly early stages of 2nd dose roll out of AZ (9-11 week interval would suggest starting maybe in th…
We’re still in the fairly early stages of 2nd dose roll out of AZ (9-11 week interval would suggest starting maybe in the 2nd week in March) and it is possible that immunity build up post second dose is slower than Pfizer but ends up roughly equivalent. h
@ktoomanybooks @steber232 @fascinatorfun @trishgreenhalgh @PHE_uk Here's a theory why might happen though https://t.co/c39BJuYvA8
RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…
RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…
RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…
RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…
Výhoda adenovirových vakcín: virové nosiče jsou odolné. Některým trvá dlouho, než se dostanou do buněk, kde začnou vyrábět S-protein, tělo se tak s ním potkává dlouho (týdny-měsíce?) a zvedá tak imunitní odpověď. Proto AZ vyžaduje přeočkování až po 3 měsíc
RT @DevanSinha: @AntellPhilippa NYT overview of ChAdOx1 mechanism (source of pics): https://t.co/dwMI7SBLXc More detailed science papers…
RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…
Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate immune system: https://t.co/tjbuy9Q8Hu Especially T-cells: https://t.co/crHu4fv3XH 19/ https://t.co/oYOnlbkMVO
@SamFazeli8 I've been asking that question too. Protein expression by Ad can last for weeks in mice, but (1) that's mice, and (2) I've not seen a comparison to other formats (protein, killed virus, RNA, DNA). Reference below https://t.co/pgeSP5O4XK
@cingolani_oscar por lo que veo como un obdservador ignorante de estos temas es que hace tiempo se estudia lo que en Brasil comentan y lo deben tener en cuenta cualquier fabricante de vacuna que opte por esa tecnologia para evitarlo https://t.co/ZTHU8sySsP
RT @lalbert75: @jorgeb_2021 @peterprincipio Éste artículo sobre como un vector de adenovirus no replicante puede continuar persistiendo y e…
@jorgeb_2021 @peterprincipio Éste artículo sobre como un vector de adenovirus no replicante puede continuar persistiendo y estimulando el sistema inmunológico, especialmente células T, puede interesarle. No se va a quedar a medio vacunar, el sistema inmuno
RT @DevanSinha: @AntellPhilippa NYT overview of ChAdOx1 mechanism (source of pics): https://t.co/dwMI7SBLXc More detailed science papers…
RT @michaelzlin: Review of Ad-based vaccine mechanisms below. Asserts that Ad allow enduring antigen presentation, but that's compared to p…
RT @michaelzlin: Review of Ad-based vaccine mechanisms below. Asserts that Ad allow enduring antigen presentation, but that's compared to p…
RT @michaelzlin: Review of Ad-based vaccine mechanisms below. Asserts that Ad allow enduring antigen presentation, but that's compared to p…
RT @michaelzlin: Review of Ad-based vaccine mechanisms below. Asserts that Ad allow enduring antigen presentation, but that's compared to p…
Review of Ad-based vaccine mechanisms below. Asserts that Ad allow enduring antigen presentation, but that's compared to protein or killed virus, not RNA. Regardless once lymphocytes are activated, they will live much longer than Ad or RNA can express. htt
@ignaziowinner @Karl_Lauterbach Ja, das ist interessant. Hier gibt es noch ein paar Infos. https://t.co/0ZgI2K1lnr
@JPabloReisch Mijo eso wue midieron ahí, no es la única forma en la que la vacuna induce inmunidad. https://t.co/CB9UQFgFxH
@zur_not_doc Studien mit AZ speziell habe ich nicht parat, aber Vektorimmunität war schon bei Gentherapien immer ein Thema. Deshalb nutzt Sputnik V zwei verschiedene adenovirale Vektoren. https://t.co/bnG0FSxMly https://t.co/O2FBG9c1m1 https://t.co/3oa0
@edalgomezn @bacigalupe @micronauta @elaval @rafaelg_fisica @Censelio @nbody6 @PolarBearby Solo considera nivel de anticuerpos... pero... https://t.co/CB9UQFgFxH
@jorgeb_2021 Por eso es tan interesante el mecanismo de una vacuna como OX/AZ. Hay artículos científicos detallados sobre cómo incluso el vector de adenovirus no replicante puede continuar persistiendo y estimulando el sistema inmunológico. Especialmente c
@declamare @TheGazmanRants These were some papers I cited in a thread trying to explain then different protection dynamics between advector and mrna vax. might be what you're after. https://t.co/Bq2eWTGXNU
@ProtEngineer @chiara_rapi Agreed on some CAR usage, but also some as-yet unknown receptor(s). Uptake by muscle cells at injection site, some uptake in dLNs by APCs, including DCs. More info here: https://t.co/law69WLgub & https://t.co/sFKeOFpufJ 😊 htt
@AntellPhilippa NYT overview of ChAdOx1 mechanism (source of pics): https://t.co/dwMI7SBLXc More detailed science papers on how even non-replicating adenovirus vector can continue to persist and stimulate immune system: https://t.co/tjbuy9Q8Hu Especial
@LouDeFrogg @Cs_Madrid Efectivamente, y para ser correctos, no es el adenovirus el que entra en el núcleo, sino su ADN. A diferencia de otros, como los retrovirus, no se integran en el ADN genómico celular. Si está interesada en conocer su mecanismo de ac
@InCytometry Well might I do some shameless self promotion 💁🏼♀️ but I hope you will find much of the info you are looking for here https://t.co/Fn6FEPEvlH
RT @Virusnerdette: @__philipn__ In summary, it's complicated. There is a hierarchy of immunogenicity. Multiple factors likely contribute to…
@__philipn__ In summary, it's complicated. There is a hierarchy of immunogenicity. Multiple factors likely contribute to differences https://t.co/mpMTLaVpIf
@surnell @Prasannasimha @Swamy39 This is a good review on adenoviral vectors if you are interested to understand why testing in an indian context is important https://t.co/eDO7mF0EZ5
@DrEricDing Data uncertainty regarding Oxford's coronavirus vaccine, MORE 🔽: "Furthermore, the excessive induction of Type I interferons by some Ad vectors has been suggested to impair transgene expression levels, dampening subsequent immune responses."
Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines https://t.co/9pKid7aYlV
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8 https://t.co/XNt0ms2zmZ
Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines https://t.co/TAkE8lrz2c
RT @FrontImmunol: New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral…
RT @FrontImmunol: New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral…
RT @FrontImmunol: New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral…
RT @FrontImmunol: New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral…
RT @FrontImmunol: New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral…
RT @FrontImmunol: New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral…
RT @FrontImmunol: New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral…
New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral vectors are a safe and potently immunogenic vaccine delivery platform. Non-replicating Ad vectors possess several… https://t.co/dcVfStv
RT @SimonWad: Nice review on factors contributing to immunogenicity of non-replicating adenovirus vectors from @Virusnerdette 👏🏻👏🏻👏🏻 @alanl…
RT @SimonWad: Nice review on factors contributing to immunogenicity of non-replicating adenovirus vectors from @Virusnerdette 👏🏻👏🏻👏🏻 @alanl…
RT @SimonWad: Nice review on factors contributing to immunogenicity of non-replicating adenovirus vectors from @Virusnerdette 👏🏻👏🏻👏🏻 @alanl…
RT @SimonWad: Nice review on factors contributing to immunogenicity of non-replicating adenovirus vectors from @Virusnerdette 👏🏻👏🏻👏🏻 @alanl…
Nice review on factors contributing to immunogenicity of non-replicating adenovirus vectors from @Virusnerdette 👏🏻👏🏻👏🏻 @alanlparker @Dr_RKarda @DrJo_Ng @RickPrivolizzi @jantinaod https://t.co/onasfjEPhG