Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice

Overview of attention for article published in Nature Communications, June 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

news
14 news outlets
blogs
2 blogs
twitter
14 tweeters

Readers on

mendeley
28 Mendeley
Title
Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice
Published in
Nature Communications, June 2016
DOI 10.1038/ncomms11761
Pubmed ID
Authors

V. Beglopoulos, J. Tulloch, A. D. Roe, S. Daumas, L. Ferrington, R. Watson, Z. Fan, B. T. Hyman, P. A. T. Kelly, F. Bard, R. G. M. Morris, Beglopoulos, V, Tulloch, J, Roe, A D, Daumas, S, Ferrington, L, Watson, R, Fan, Z, Hyman, B T, Kelly, P A T, Bard, F, Morris, R G M

Abstract

Earlier diagnosis and treatment of Alzheimer's disease would greatly benefit from the identification of biomarkers at the prodromal stage. Using a prominent animal model of aspects of the disease, we here show using clinically relevant methodologies that very young, pre-pathological PDAPP mice, which overexpress mutant human amyloid precursor protein in the brain, exhibit two cryptic deficits that are normally undetected using standard methods of assessment. Despite learning a spatial memory task normally and displaying normal brain glucose uptake, they display faster forgetting after a long delay following performance to a criterion, together with a strong impairment of brain glucose uptake at the time of attempted memory retrieval. Preliminary observations suggest that these deficits, likely caused by an impairment in systems consolidation, could be rescued by immunotherapy with an anti-β-amyloid antibody. Our data suggest a biomarker strategy for the early detection of β-amyloid-related abnormalities.

Twitter Demographics

The data shown below were collected from the profiles of 14 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 4%
France 1 4%
Unknown 26 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 32%
Researcher 6 21%
Student > Master 4 14%
Librarian 2 7%
Student > Bachelor 2 7%
Other 5 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 43%
Neuroscience 7 25%
Biochemistry, Genetics and Molecular Biology 3 11%
Medicine and Dentistry 3 11%
Environmental Science 1 4%
Other 2 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 130. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2016.
All research outputs
#50,098
of 7,573,453 outputs
Outputs from Nature Communications
#824
of 11,504 outputs
Outputs of similar age
#4,251
of 266,809 outputs
Outputs of similar age from Nature Communications
#83
of 792 outputs
Altmetric has tracked 7,573,453 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,504 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.9. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,809 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 792 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.