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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement
|
|---|---|
| Published in |
Nature Communications, June 2016
|
| DOI | 10.1038/ncomms11753 |
| Pubmed ID | |
| Authors |
Lawrence S. Hsieh, John H. Wen, Kumiko Claycomb, Yuegao Huang, Felicia A. Harrsch, Janice R. Naegele, Fahmeed Hyder, Gordon F. Buchanan, Angelique Bordey |
| Abstract |
Focal cortical dysplasia (FCD), a local malformation of cortical development, is the most common cause of pharmacoresistant epilepsy associated with life-long neurocognitive impairments. It remains unclear whether neuronal misplacement is required for seizure activity. Here we show that dyslamination and white matter heterotopia are not necessary for seizure generation in a murine model of type II FCDs. These experimental FCDs generated by increasing mTOR activity in layer 2/3 neurons of the medial prefrontal cortex are associated with tonic-clonic seizures and a normal survival rate. Preventing all FCD-related defects, including neuronal misplacement and dysmorphogenesis, with rapamycin treatments from birth eliminates seizures, but seizures recur after rapamycin withdrawal. In addition, bypassing neuronal misplacement and heterotopia using inducible vectors do not prevent seizure occurrence. Collectively, data obtained using our new experimental FCD-associated epilepsy suggest that life-long treatment to reduce neuronal dysmorphogenesis is required to suppress seizures in individuals with FCD. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 45% |
| Japan | 1 | 9% |
| Unknown | 5 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 82% |
| Practitioners (doctors, other healthcare professionals) | 1 | 9% |
| Science communicators (journalists, bloggers, editors) | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 105 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 21% |
| Student > Ph. D. Student | 15 | 14% |
| Student > Doctoral Student | 9 | 8% |
| Student > Master | 8 | 7% |
| Professor | 5 | 5% |
| Other | 18 | 17% |
| Unknown | 30 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 29 | 27% |
| Biochemistry, Genetics and Molecular Biology | 13 | 12% |
| Agricultural and Biological Sciences | 13 | 12% |
| Medicine and Dentistry | 12 | 11% |
| Immunology and Microbiology | 1 | <1% |
| Other | 5 | 5% |
| Unknown | 34 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2016.
All research outputs
#1,726,632
of 22,875,477 outputs
Outputs from Nature Communications
#22,073
of 47,117 outputs
Outputs of similar age
#33,115
of 339,120 outputs
Outputs of similar age from Nature Communications
#359
of 812 outputs
Altmetric has tracked 22,875,477 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 47,117 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.8. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 339,120 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 812 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.