Title |
High MCM3 expression is an independent biomarker of poor prognosis and correlates with reduced RBM3 expression in a prospective cohort of malignant melanoma
|
---|---|
Published in |
Diagnostic Pathology, July 2012
|
DOI | 10.1186/1746-1596-7-82 |
Pubmed ID | |
Authors |
Björn Nodin, Marie Fridberg, Liv Jonsson, Julia Bergman, Mathias Uhlén, Karin Jirström |
Abstract |
Malignant melanoma is the most lethal form of skin cancer with a variable clinical course even in patients with thin melanomas and localized disease. Despite increasing insights into melanoma biology, no prognostic biomarkers have yet been incorporated into clinical protocols. Reduced expression of the RNA binding motif protein 3 (RBM3) has been shown to correlate with tumour progression and poor prognosis in melanoma and several other cancer forms. In ovarian cancer, an inverse association was found between expression of RBM3 and the minichromosome maintenance 3 (MCM3) gene and protein. In melanoma, gene expression analysis and immunohistochemical validation has uncovered MCM3 as a putative prognostic biomarker. The aim of the present study was to examine the associations of MCM3 expression with clinical outcome and RBM3 expression in a prospective, population-based cohort of melanoma. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 22% |
Researcher | 5 | 14% |
Student > Master | 4 | 11% |
Student > Postgraduate | 2 | 6% |
Professor > Associate Professor | 2 | 6% |
Other | 5 | 14% |
Unknown | 10 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 19% |
Biochemistry, Genetics and Molecular Biology | 5 | 14% |
Agricultural and Biological Sciences | 5 | 14% |
Business, Management and Accounting | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Other | 4 | 11% |
Unknown | 13 | 36% |