Title |
Poor sensitization of 50-kHz vocalization response to amphetamine predicts rat susceptibility to self-administration of the drug
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Published in |
Psychopharmacology, June 2016
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DOI | 10.1007/s00213-016-4328-4 |
Pubmed ID | |
Authors |
Ewa Taracha, Ewelina Kaniuga, Edyta Wyszogrodzka, Adam Płaźnik, Roman Stefański, Stanisław J. Chrapusta |
Abstract |
Our previous studies showed promise for using sensitization of the frequency-modulated 50-kHz vocalization response to amphetamine (AMPH) as an index of rat vulnerability to AMPH addiction. This study aimed to test the utility of sensitizing frequency-modulated (FM) 50-kHz vocalization in the AMPH self-administration paradigm as well as the ability of N-acetylcysteine to prevent self-administration relapse. Rats were subjected to the so-called two-injection protocol of sensitization (TIPS) using AMPH and were categorized as low-sensitized callers (LCTIPS) or high-sensitized callers (HCTIPS) based on the individual outcomes. Then, they were given 44 sessions of AMPH self-administration followed by a 17-session N-acetylcysteine-aided extinction course and a single session of AMPH-primed self-administration reinstatement. LCTIPS compared to HCTIPS rats showed no considerable difference in the FM 50-kHz vocalization rate during the self-administration training or extinction course, but they were considerably more likely to acquire AMPH self-administration and experience drug-induced reinstatement of this trait. Moreover, the LCTIPS rats were more likely than HCTIPS rats to have a markedly higher FM 50-kHz vocalization rate after AMPH reinstatement. N-acetylcysteine did not affect the course of self-administration extinction or the instrumental or FM 50-kHz vocalization responses to AMPH reinstatement. There is no link between the FM 50-kHz vocalization and key characteristics of AMPH self-administration. Additionally, N-acetylcysteine does not help prevent AMPH self-administration relapse. However, there is a high predictive value for poor sensitization of the FM 50-kHz vocalization response to AMPH with respect to the acquisition and maintenance of self-administration of this psychostimulant. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 20% |
Student > Bachelor | 3 | 15% |
Researcher | 3 | 15% |
Professor | 2 | 10% |
Professor > Associate Professor | 2 | 10% |
Other | 2 | 10% |
Unknown | 4 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 5 | 25% |
Agricultural and Biological Sciences | 4 | 20% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Sports and Recreations | 1 | 5% |
Other | 3 | 15% |
Unknown | 5 | 25% |