Title |
Genetic diversity of expressed Plasmodium falciparum var genes from Tanzanian children with severe malaria
|
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Published in |
Malaria Journal, July 2012
|
DOI | 10.1186/1475-2875-11-230 |
Pubmed ID | |
Authors |
Joseph Mugasa, Weihong Qi, Sebastian Rusch, Matthias Rottmann, Hans-Peter Beck |
Abstract |
Severe malaria has been attributed to the expression of a restricted subset of the var multi-gene family, which encodes for Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 mediates cytoadherence and sequestration of infected erythrocytes into the post-capillary venules of vital organs such as the brain, lung or placenta. var genes are highly diverse and can be classified in three major groups (ups A, B and C) and two intermediate groups (B/A and B/C) based on the genomic location, gene orientation and upstream sequences. The genetic diversity of expressed var genes in relation to severity of disease in Tanzanian children was analysed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Tanzania, United Republic of | 2 | 2% |
Kenya | 2 | 2% |
Indonesia | 1 | 1% |
France | 1 | 1% |
Australia | 1 | 1% |
United Kingdom | 1 | 1% |
Denmark | 1 | 1% |
Unknown | 75 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 22 | 26% |
Researcher | 12 | 14% |
Student > Bachelor | 12 | 14% |
Student > Master | 8 | 10% |
Other | 5 | 6% |
Other | 11 | 13% |
Unknown | 14 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 29 | 35% |
Medicine and Dentistry | 12 | 14% |
Biochemistry, Genetics and Molecular Biology | 12 | 14% |
Immunology and Microbiology | 4 | 5% |
Computer Science | 3 | 4% |
Other | 8 | 10% |
Unknown | 16 | 19% |