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Genetic diversity of expressed Plasmodium falciparum var genes from Tanzanian children with severe malaria

Overview of attention for article published in Malaria Journal, July 2012
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Title
Genetic diversity of expressed Plasmodium falciparum var genes from Tanzanian children with severe malaria
Published in
Malaria Journal, July 2012
DOI 10.1186/1475-2875-11-230
Pubmed ID
Authors

Joseph Mugasa, Weihong Qi, Sebastian Rusch, Matthias Rottmann, Hans-Peter Beck

Abstract

Severe malaria has been attributed to the expression of a restricted subset of the var multi-gene family, which encodes for Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 mediates cytoadherence and sequestration of infected erythrocytes into the post-capillary venules of vital organs such as the brain, lung or placenta. var genes are highly diverse and can be classified in three major groups (ups A, B and C) and two intermediate groups (B/A and B/C) based on the genomic location, gene orientation and upstream sequences. The genetic diversity of expressed var genes in relation to severity of disease in Tanzanian children was analysed.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Tanzania, United Republic of 2 2%
Kenya 2 2%
Indonesia 1 1%
France 1 1%
Australia 1 1%
United Kingdom 1 1%
Denmark 1 1%
Unknown 75 89%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 26%
Researcher 12 14%
Student > Bachelor 12 14%
Student > Master 8 10%
Other 5 6%
Other 11 13%
Unknown 14 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 29 35%
Medicine and Dentistry 12 14%
Biochemistry, Genetics and Molecular Biology 12 14%
Immunology and Microbiology 4 5%
Computer Science 3 4%
Other 8 10%
Unknown 16 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2012.
All research outputs
#18,310,549
of 22,671,366 outputs
Outputs from Malaria Journal
#5,015
of 5,540 outputs
Outputs of similar age
#125,794
of 163,495 outputs
Outputs of similar age from Malaria Journal
#74
of 87 outputs
Altmetric has tracked 22,671,366 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,540 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
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We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.