@tgof137 @AndrewButchart1 @abhishek_s_1 @arguablywrong @stevenemassey @nizzaneela @slatestarcodex Average exposed to infectious for G614 is 5 days (Eo), and average infectous is 2 days (Do), hence serial interval 7 days. For D614 (early Wuhan) I used 7 da
@mbw61567742 @_everythingism @ban_epp_gofroc @FairyCalvo I don’t get your point here. The D614G variant emerged after the virus was already spreading in humans. The fact that it can’t propagate in raccoon dogs doesn’t seem relevant here. If you have a stu
@MechaZia @_stopwhispering @reg_mati Deje de repetir pavadas e ilústrese https://t.co/XOUHPxOmc6
18. D614G (3) Evidence that D614G Increases Infectivity of the COVID19 Virus https://t.co/goHfVSUpvJ D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity https://t.co/STiFYs7tjR
@MJnanostretch FYI, from seminal paper by Korber et al '20: "...studies show that patients infected w/G614 shed more viral nucleic acid compared with those w/D614, & G614-bearing viruses show significantly higher infectious titers in vitro than their D
RT @GringoGranadino: https://t.co/90n7XTwsku Covid mutates rapidly ans you can get it overans over again
@Biorealism @EmaNymton90 Ref (57) from Guo...Gould is a must read. Earliest detection of 614G is Jan2020. To highlight Gould, Ema and tons of others, the time from FCS appearance to 614G really constrains the timing (and size?) in the transitional pool of
@Biorealism @EmaNymton90 Ref (57) from Guo...Gould is a must read. Earliest detection of 614G is Jan2020. To highlight Gould, Ema and tons of others, the time from FCS appearance and 614G really constrains the timing (and size?) of the transitional pool of
RT @SolidEvidence: Surprisingly, we don’t really know how or where A->B.1. We don’t know what order the mutations were picked up, and we do…
@the_mopster @VikiLovesFACS @SGriffin_Lab @BawdenTom @bmj_latest @chrischirp @dgurdasani1 @katebrown220 SARS-CoV-2 has a very small mutation rate v other coronaviruses. Unfortunately due to NO long term testing immune escape was imminent as many scientis
RT @GringoGranadino: https://t.co/90n7XTwsku Covid mutates rapidly ans you can get it overans over again
@jhas5 @tony_vandongen IMO D614 was too pathogenic to peak unnoticed in Asia (and without leaving Ab traces). The precursor must have been milder. The previous step in a increasing severity path (until it hit the immunity wall): Precursor->D614->G6
RT @SolidEvidence: Surprisingly, we don’t really know how or where A->B.1. We don’t know what order the mutations were picked up, and we do…
RT @SolidEvidence: Surprisingly, we don’t really know how or where A->B.1. We don’t know what order the mutations were picked up, and we do…
@SolidEvidence That paper was also the most useful resource I found when trying to understand the emergence of B.1 (D614G), especially some of the map/graph figures, eg👇, but I’ve felt like I must be missing something It’s a bit disconcerting to know that
RT @SolidEvidence: Surprisingly, we don’t really know how or where A->B.1. We don’t know what order the mutations were picked up, and we do…
RT @SolidEvidence: Surprisingly, we don’t really know how or where A->B.1. We don’t know what order the mutations were picked up, and we do…
RT @SolidEvidence: Surprisingly, we don’t really know how or where A->B.1. We don’t know what order the mutations were picked up, and we do…
RT @SolidEvidence: Surprisingly, we don’t really know how or where A->B.1. We don’t know what order the mutations were picked up, and we do…
RT @SolidEvidence: Surprisingly, we don’t really know how or where A->B.1. We don’t know what order the mutations were picked up, and we do…
RT @SolidEvidence: Surprisingly, we don’t really know how or where A->B.1. We don’t know what order the mutations were picked up, and we do…
RT @SolidEvidence: Surprisingly, we don’t really know how or where A->B.1. We don’t know what order the mutations were picked up, and we do…
RT @SolidEvidence: Surprisingly, we don’t really know how or where A->B.1. We don’t know what order the mutations were picked up, and we do…
RT @SolidEvidence: Surprisingly, we don’t really know how or where A->B.1. We don’t know what order the mutations were picked up, and we do…
Surprisingly, we don’t really know how or where A->B.1. We don’t know what order the mutations were picked up, and we don’t know what country it occurred in. Bette Korber tried to sort this out, but it wasn’t really resolved. Adapted from her paper. 1
@franciscodeasis @virologyanon @CD57227 Plus, Fig1A of Korber etal '20 shows far more D614G samples from Europe vs China (prior to Mar '20), indicating D614G actually may have independently evolved 1st in Germany (see Ger. graph in Fig2B). Undercuts narrat
@Nodo23049099 @GibertiePatrice C'était plutôt faux en fait. https://t.co/bQ9RrhLkmE
@anxeru @tony_vandongen @mrandersoninneo @Nemesis_Alert @R_H_Ebright @m80889506 D614 was in fact less severe than G614, but not mild enough to go undetected while infecting a significant % of the population (e.g. 38% to help NPIs stop G614). The pre-pande
@alchemytoday @EmaNymton90 @Ayjchan "The Spike D614G amino acid change is caused by an A-to-G nucleotide mutation at position 23,403 in Wuhan reference strain; it was the only site identified in our 1st Spike variation analysis in early Mar '20...At that t
@DrPaulOffit I know this isn’t your article’s focus, but I have a ? re early evolution to 614G My understanding👇 is that 614G dominated early major hotspots w high death rates (e.g. Lombardy, NYC) but not many of those that did fairly well (e.g. Seattle)—
@Ticklicker56 Sorry, I am a bit busy today! But I agree with your approach 👍🏻 Maybe you were referring to this study https://t.co/qi0acgGKrz
RT @GringoGranadino: https://t.co/90n7XTwsku Covid mutates rapidly ans you can get it overans over again
RT @GringoGranadino: https://t.co/90n7XTwsku Covid mutates rapidly ans you can get it overans over again
RT @GringoGranadino: https://t.co/90n7XTwsku Covid mutates rapidly ans you can get it overans over again
RT @GringoGranadino: https://t.co/90n7XTwsku Covid mutates rapidly ans you can get it overans over again
RT @GringoGranadino: https://t.co/90n7XTwsku Covid mutates rapidly ans you can get it overans over again
@Daoyu15 @EWoodhouse7 At continent level D614 had initially more prevalence thsn G614 everywhere, but in South America. (and in Italy too, by less margin though) https://t.co/Df7AVs6Pan. https://t.co/djW6PEOC3u
RT @GringoGranadino: https://t.co/90n7XTwsku Covid mutates rapidly ans you can get it overans over again
RT @LDjaparidze: Revisiting Korber et al. paper https://t.co/5wlUQuEU9L G614 variant was more severe than variant D614 (Fisher's exact te…
RT @LDjaparidze: Revisiting Korber et al. paper https://t.co/5wlUQuEU9L G614 variant was more severe than variant D614 (Fisher's exact te…
RT @CD57227: @VBruttel @R_H_Ebright @mbalter @JamieMetzl @WashburneAlex You're right! The isolate from the first cluster in Germany (detect…
RT @CD57227: @VBruttel @R_H_Ebright @mbalter @JamieMetzl @WashburneAlex You're right! The isolate from the first cluster in Germany (detect…
RT @CD57227: @VBruttel @R_H_Ebright @mbalter @JamieMetzl @WashburneAlex You're right! The isolate from the first cluster in Germany (detect…
Nearly all so-called “science” journalists aren’t intelligent enough to understand what is being said here, and its implications for the desperate theory that Covid was somehow started by raccoon dogs at a wet market in Wuhan (right down the block from the
RT @CD57227: @VBruttel @R_H_Ebright @mbalter @JamieMetzl @WashburneAlex You're right! The isolate from the first cluster in Germany (detect…
DOD proposal to use Gain of function of Covid to prevent the possible future infection of our troops. EcoHealth alliance and Daszak Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus @VigilantFox https:
RT @CD57227: @VBruttel @R_H_Ebright @mbalter @JamieMetzl @WashburneAlex You're right! The isolate from the first cluster in Germany (detect…
RT @CD57227: @VBruttel @R_H_Ebright @mbalter @JamieMetzl @WashburneAlex You're right! The isolate from the first cluster in Germany (detect…
@VBruttel @R_H_Ebright @mbalter @JamieMetzl @WashburneAlex You're right! The isolate from the first cluster in Germany (detected on 27 Jan 2020) was used to infect the raccoon dogs at the Friedrich-Loeffler-Institut, and it had the D614G mutation already 🤯
@WashburneAlex @dayou15 It arose after the FCS. People seem to forget this. D614 was in circulation for awhile until it was replaced by G614. https://t.co/liixmfym6K
@simon_gordon_ @TotalCytopath @BrianRWasik g614 all but drove d614 to extinction https://t.co/MXiEt7z3hq https://t.co/mXNcCYVbYZ
@Weavz @Archie_155 @MolonMemes58 @VigilantFox Here’s some evidence but not sure what exactly you want to see. Your turn… https://t.co/sQrCoylDHP
@TheSiNNOVATE @MolonMemes58 @VigilantFox Sure. Already did several times. Now your chance. Lab leak proof please. https://t.co/WCqyWf9te7
RT @GringoGranadino: https://t.co/90n7XTwsku Covid mutates rapidly ans you can get it overans over again
RT @GringoGranadino: https://t.co/90n7XTwsku Covid mutates rapidly ans you can get it overans over again
RT @GringoGranadino: https://t.co/90n7XTwsku Covid mutates rapidly ans you can get it overans over again
RT @GringoGranadino: https://t.co/90n7XTwsku Covid mutates rapidly ans you can get it overans over again
RT @GringoGranadino: https://t.co/90n7XTwsku Covid mutates rapidly ans you can get it overans over again
https://t.co/90n7XTwsku Covid mutates rapidly ans you can get it overans over again
RT @GringoGranadino: https://t.co/90n7XTwsku Covid mutates rapidly ans you can get it overans over again
RT @GringoGranadino: https://t.co/90n7XTwsku Covid mutates rapidly ans you can get it overans over again
https://t.co/90n7XTwsku Covid mutates rapidly ans you can get it overans over again
RT @LDjaparidze: @quay_dr Not possible. G614 was more transmissible than D614. If G614 had jumped in first, D614 would never have circulate…
@quay_dr Not possible. G614 was more transmissible than D614. If G614 had jumped in first, D614 would never have circulated and it did so massively before G614 replaced it everywhere. https://t.co/5wlUQuEU9L
@Peter_InNorfolk It is reasonable, but not possible. D614's transmissibility and severity were lower than G614's, but high enough to create notable waves of deaths. The variant of the early Asian wave must have been considerably less severe than D614. h
@EWoodhouse7 I know it doesn’t fit your narrative, but you really should read this paper👇
@boriquagato @EWoodhouse7 @cpcriser @jengleruk @drop_robert @Hold2LLC @justin_hart I’m definitely not an expert on early COVID strains, but it seems reasonable to suspect that the D614G mutation played at least a somewhat important role in the timing of Lo
RT @federicolois: Korber et al. A key piece in our Asian Hypothesis with @LDjaparidze . This is a very important paper that has mostly pass…
RT @federicolois: Korber et al. A key piece in our Asian Hypothesis with @LDjaparidze . This is a very important paper that has mostly pass…
RT @federicolois: Korber et al. A key piece in our Asian Hypothesis with @LDjaparidze . This is a very important paper that has mostly pass…
RT @federicolois: Korber et al. A key piece in our Asian Hypothesis with @LDjaparidze . This is a very important paper that has mostly pass…
Korber et al. A key piece in our Asian Hypothesis with @LDjaparidze . This is a very important paper that has mostly passed under the radar for most. It shows how D614 variant was superseded by the more aggressive G614. Under viral competence, either you r
Revisiting Korber et al. paper https://t.co/5wlUQuEU9L G614 variant was more severe than variant D614 (Fisher's exact test two-tailed P value equals 0.0467) when measured as patient ICU admissions over IP+OP (inpatient + outpatient). https://t.co/JpONKKG
@Nemesis_Alert @PeterJAnderson_ @CharlesRixey @asrayagiriraj @AlexisBadenMaye @alexandrosM @Ayjchan @emilyakopp Vaguely...the NIH did some papers relating the two D614G & G614 neatly delineating both & supporting KG's gang here ; https://t.co/8Qhv
@2dedostesta2 @AtomsksSanakan @alchemytoday @MichaelWorobey @ScienceMagazine D613G probably arose more than once, incl early in EU https://t.co/cM04XGI7wY <img src="https://t.co/KBPbZNCN10" alt="An external file that holds a picture, illustration, etc.
@stevenemassey @lab_leak While this was published in early July: https://t.co/zh7d5GnfwB
RT @MdFacep: Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus https://t.co/iyxuOp7lx7
Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus https://t.co/iyxuOp7lx7
RT @ScienceBeTold: @Covid19Crusher 2/ one could superimpose the Cato work with work from Los Almos National Lab (https://t.co/OlovvDe01A),…
RT @ScienceBeTold: @gummibear737 @clairlemon One of the most under-stated facts in Pandemic is that countries are dealing with different vi…
@ComteOblivion @YanConstantin @AlexSamTG Avec lui pas compliqué: Le reste du monde... Juillet 2020, soumis en avril 2020... https://t.co/NGd2jwt3jV
#Sars Satellites https://t.co/mnCpG6XLgB
@SixandLaura @edyong209 No, I was referring to the Korber et al. paper here: https://t.co/ZnCEVYh88O. That came out as a preprint in April or May 2020. I am not aware of any paper that has shown changes in the rate of viral evolution.
RT @topolj: @mtosterholm You misspoke on Morning Joe when you called the UK variant the first more transmissible variant. The press mishand…
The 1st recognized mutation in #SARSCoV2 in 2020 to increase infectiousness: "The transition from D614 to G614 occurred asynchronously in different regions throughout the world, beginning in Europe, followed by North America and Oceania and then Asia."