↓ Skip to main content

Matrix metalloproteinase protein expression profiles cannot distinguish between normal and early osteoarthritic synovial fluid

Overview of attention for article published in BMC Musculoskeletal Disorders, July 2012
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age

Mentioned by

twitter
2 tweeters

Citations

dimensions_citation
25 Dimensions

Readers on

mendeley
51 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Matrix metalloproteinase protein expression profiles cannot distinguish between normal and early osteoarthritic synovial fluid
Published in
BMC Musculoskeletal Disorders, July 2012
DOI 10.1186/1471-2474-13-126
Pubmed ID
Authors

Bryan J Heard, Liam Martin, Jerome B Rattner, Cyril B Frank, David A Hart, Roman Krawetz

Abstract

Osteoarthritis (OA) and rheumatoid arthritis (RA) are diseases which result in the degeneration of the joint surface articular cartilage. Matrix metalloproteinases (MMPs) are enzymes that aid in the natural remodelling of tissues throughout the body including cartilage. However, some MMPs have been implicated in the progression of OA and RA as their expression levels and activation states can change dramatically with the onset of disease. Yet, it remains unknown if normal and arthritic joints demonstrate unique MMPs expression profiles, and if so, can the MMP expression profile be used to identify patients with early OA. In this study, the synovial fluid protein expression levels for MMPs 1, 2, 3, 7, 8, 9, 12 & 13, as well as those for the Tissue Inhibitors of MMPs (TIMPs) 1, 2, 3, & 4 were examined in highly characterized normal knee joints, and knee joints with clinically diagnosed OA (early and advanced) or RA. The purpose of this study was to determine if normal, OA, and RA patients exhibit unique expression profiles for a sub-set of MMPs, and if early OA patients have a unique MMP expression profile that could be used as an early diagnostic marker.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 50 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 22%
Student > Ph. D. Student 11 22%
Unspecified 8 16%
Student > Master 6 12%
Professor 4 8%
Other 11 22%
Readers by discipline Count As %
Medicine and Dentistry 20 39%
Unspecified 9 18%
Agricultural and Biological Sciences 7 14%
Engineering 4 8%
Sports and Recreations 2 4%
Other 9 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2012.
All research outputs
#7,762,737
of 12,373,620 outputs
Outputs from BMC Musculoskeletal Disorders
#1,521
of 2,454 outputs
Outputs of similar age
#68,512
of 121,455 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#17
of 28 outputs
Altmetric has tracked 12,373,620 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,454 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 121,455 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.