Title |
Thrombotic microangiopathy associated with use of interferon-beta
|
---|---|
Published in |
International Journal of Nephrology and Renovascular Disease, June 2012
|
DOI | 10.2147/ijnrd.s30194 |
Pubmed ID | |
Authors |
Teresa Olea, Raquel Díaz-Mancebo, Maria-Luz Picazo, Jorge Martínez-Ara, Angel Robles, Rafael Selgas |
Abstract |
Interferon-beta is widely used for the treatment of relapsing multiple sclerosis. The drug is usually well tolerated, but autoimmune adverse effects, including kidney disease, have been reported. Only a few cases of hemolytic uremic syndrome-thrombotic microangiopathy associated interferon-alpha have been described so far, and even fewer with beta-interferon. We report a patient who developed thrombotic microangiopathy during treatment with interferon-beta and improved after discontinuation and steroid therapy. Complement cascade and antiphospholipid antibodies are investigated. The spectrum of renal diseases associated with interferon-beta treatment is also reviewed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Argentina | 1 | 5% |
Unknown | 19 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 25% |
Researcher | 2 | 10% |
Student > Postgraduate | 2 | 10% |
Professor > Associate Professor | 2 | 10% |
Student > Master | 2 | 10% |
Other | 4 | 20% |
Unknown | 3 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 25% |
Agricultural and Biological Sciences | 5 | 25% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Neuroscience | 2 | 10% |
Psychology | 1 | 5% |
Other | 0 | 0% |
Unknown | 5 | 25% |