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Neuroimmune endocrine effects of antidepressants

Overview of attention for article published in Neuropsychiatric Disease and Treatment, February 2012
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1 X user

Citations

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38 Dimensions

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99 Mendeley
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1 CiteULike
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Title
Neuroimmune endocrine effects of antidepressants
Published in
Neuropsychiatric Disease and Treatment, February 2012
DOI 10.2147/ndt.s16409
Pubmed ID
Authors

Marco Antonioli, Joanna Rybka, Livia A Carvalho

Abstract

Antidepressant pharmacotherapy is to date the most often used treatment for depression, but the exact mechanism of action underlying its therapeutic effect is still unclear. Many theories have been put forward to account for depression, as well as antidepressant activity, but none of them is exhaustive. Neuroimmune endocrine impairment is found in depressed patients; high levels of circulating corticosteroids along with hyperactivation of the immune system, high levels of proinflammatory cytokines, low levels of melatonin in plasma and urine, and disentrainment of circadian rhythms have been demonstrated. Moreover, antidepressant treatment seems to correct or at least to interfere with these alterations. In this review, we summarize the complex neuroimmune endocrine and chronobiological alterations found in patients with depression and how these systems interact with each other. We also explain how antidepressant therapy can modify these systems, along with some possible mechanisms of action shown in animal and human models.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 1%
Spain 1 1%
Poland 1 1%
Germany 1 1%
Unknown 95 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 20%
Student > Master 17 17%
Researcher 13 13%
Student > Bachelor 10 10%
Other 9 9%
Other 16 16%
Unknown 14 14%
Readers by discipline Count As %
Medicine and Dentistry 25 25%
Agricultural and Biological Sciences 18 18%
Psychology 16 16%
Neuroscience 8 8%
Pharmacology, Toxicology and Pharmaceutical Science 6 6%
Other 7 7%
Unknown 19 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2015.
All research outputs
#20,656,161
of 25,374,647 outputs
Outputs from Neuropsychiatric Disease and Treatment
#2,328
of 3,132 outputs
Outputs of similar age
#205,115
of 253,532 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#7
of 9 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,132 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 253,532 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.