Title |
Amyotrophic lateral sclerosis: update and new developments
|
---|---|
Published in |
Degenerative Neurological and Neuromuscular Disease, February 2012
|
DOI | 10.2147/dnnd.s19803 |
Pubmed ID | |
Authors |
Ashley J Pratt, Elizabeth D Getzoff, J Jefferson P Perry |
Abstract |
Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease. It is typically characterized by adult-onset degeneration of the upper and lower motor neurons, and is usually fatal within a few years of onset. A subset of ALS patients has an inherited form of the disease, and a few of the known mutant genes identified in familial cases have also been found in sporadic forms of ALS. Precisely how the diverse ALS-linked gene products dictate the course of the disease, resulting in compromised voluntary muscular ability, is not entirely known. This review addresses the major advances that are being made in our understanding of the molecular mechanisms giving rise to the disease, which may eventually translate into new treatment options. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
Australia | 1 | <1% |
Korea, Republic of | 1 | <1% |
South Africa | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 129 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 27 | 20% |
Student > Ph. D. Student | 26 | 19% |
Student > Master | 20 | 15% |
Researcher | 18 | 13% |
Student > Postgraduate | 12 | 9% |
Other | 17 | 13% |
Unknown | 15 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 36 | 27% |
Medicine and Dentistry | 34 | 25% |
Biochemistry, Genetics and Molecular Biology | 15 | 11% |
Neuroscience | 10 | 7% |
Psychology | 5 | 4% |
Other | 15 | 11% |
Unknown | 20 | 15% |