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Attention Score in Context
| Title |
Similarities of Drosophila rab GTPases Based on Expression Profiling: Completion and Analysis of the rab-Gal4 Kit
|
|---|---|
| Published in |
PLOS ONE, July 2012
|
| DOI | 10.1371/journal.pone.0040912 |
| Pubmed ID | |
| Authors |
Eugene Jennifer Jin, Chih-Chiang Chan, Egemen Agi, Smita Cherry, Elizabeth Hanacik, Michael Buszczak, P. Robin Hiesinger |
| Abstract |
We recently generated rab-Gal4 lines for 25 of 29 predicted Drosophila rab GTPases. These lines provide tools for the expression of reporters, mutant rab variants or other genes, under control of the regulatory elements of individual rab loci. Here, we report the generation and characterization of the remaining four rab-Gal4 lines. Based on the completed 'rab-Gal4 kit' we performed a comparative analysis of the cellular and subcellular expression of all rab GTPases. This analysis includes the cellular expression patterns in characterized neuronal and non-neuronal cells and tissues, the subcellular localization of wild type, constitutively active and dominant negative rab GTPases and colocalization with known intracellular compartment markers. Our comparative analysis identifies all Rab GTPases that are expressed in the same cells and localize to the same intracellular compartments. Remarkably, similarities based on these criteria are typically not predicted by primary sequence homology. Hence, our findings provide an alternative basis to assess potential roles and redundancies based on expression in developing and adult cell types, compartment identity and subcellular localization. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 49 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 24% |
| Researcher | 8 | 16% |
| Student > Master | 6 | 12% |
| Student > Bachelor | 5 | 10% |
| Professor > Associate Professor | 4 | 8% |
| Other | 10 | 20% |
| Unknown | 6 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 41% |
| Biochemistry, Genetics and Molecular Biology | 11 | 22% |
| Neuroscience | 7 | 14% |
| Unspecified | 3 | 6% |
| Medicine and Dentistry | 2 | 4% |
| Other | 1 | 2% |
| Unknown | 6 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2012.
All research outputs
#18,312,024
of 22,673,450 outputs
Outputs from PLOS ONE
#153,783
of 193,525 outputs
Outputs of similar age
#125,924
of 164,297 outputs
Outputs of similar age from PLOS ONE
#3,143
of 3,992 outputs
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