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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Corticosteroid resistance in sepsis is influenced by microRNA-124–induced downregulation of glucocorticoid receptor-&agr;*
|
|---|---|
| Published in |
Critical Care Medicine, October 2012
|
| DOI | 10.1097/ccm.0b013e31825b8ebc |
| Pubmed ID | |
| Authors |
Carola Ledderose, Patrick Möhnle, Elisabeth Limbeck, Stefanie Schütz, Florian Weis, Jessica Rink, Josef Briegel, Simone Kreth |
| Abstract |
Acquired glucocorticoid resistance frequently complicates the therapy of sepsis. It leads to an exaggerated proinflammatory response and has been related to altered expression profiles of glucocorticoid receptor isoforms glucocorticoid receptor-α (mediating anti-inflammatory effects) and glucocorticoid receptor-β (acting as a dominant negative inhibitor). We investigated the impact of glucocorticoid receptor isoforms on glucocorticoid effects in human T-cells. We hypothesized that 1) changes of the ratio of glucocorticoid receptor isoforms impact glucocorticoid resistance and 2) glucocorticoid receptor-α expression is controlled by microRNA-mediated gene silencing. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| Mexico | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Norway | 1 | 1% |
| Belgium | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 77 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 20% |
| Student > Ph. D. Student | 13 | 16% |
| Professor | 9 | 11% |
| Student > Doctoral Student | 8 | 10% |
| Student > Master | 7 | 9% |
| Other | 16 | 20% |
| Unknown | 11 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 37 | 46% |
| Biochemistry, Genetics and Molecular Biology | 10 | 13% |
| Agricultural and Biological Sciences | 10 | 13% |
| Neuroscience | 3 | 4% |
| Psychology | 2 | 3% |
| Other | 7 | 9% |
| Unknown | 11 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2012.
All research outputs
#8,262,445
of 25,374,917 outputs
Outputs from Critical Care Medicine
#4,757
of 9,342 outputs
Outputs of similar age
#62,542
of 190,992 outputs
Outputs of similar age from Critical Care Medicine
#33
of 109 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 9,342 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 190,992 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 109 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.