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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Reactive Oxygen Species Regulate Protrusion Efficiency by Controlling Actin Dynamics
|
|---|---|
| Published in |
PLOS ONE, August 2012
|
| DOI | 10.1371/journal.pone.0041342 |
| Pubmed ID | |
| Authors |
Nicolas Taulet, Violaine D. Delorme-Walker, Céline DerMardirossian |
| Abstract |
Productive protrusions allowing motile cells to sense and migrate toward a chemotactic gradient of reactive oxygen species (ROS) require a tight control of the actin cytoskeleton. However, the mechanisms of how ROS affect cell protrusion and actin dynamics are not well elucidated yet. We show here that ROS induce the formation of a persistent protrusion. In migrating epithelial cells, protrusion of the leading edge requires the precise regulation of the lamellipodium and lamella F-actin networks. Using fluorescent speckle microscopy, we showed that, upon ROS stimulation, the F-actin retrograde flow is enhanced in the lamellipodium. This event coincides with an increase of cofilin activity, free barbed ends formation, Arp2/3 recruitment, and ERK activity at the cell edge. In addition, we observed an acceleration of the F-actin flow in the lamella of ROS-stimulated cells, which correlates with an enhancement of the cell contractility. Thus, this study demonstrates that ROS modulate both the lamellipodium and the lamella networks to control protrusion efficiency. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Russia | 1 | 2% |
| Ukraine | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 59 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 30% |
| Researcher | 11 | 17% |
| Student > Bachelor | 7 | 11% |
| Professor > Associate Professor | 7 | 11% |
| Student > Master | 6 | 9% |
| Other | 9 | 14% |
| Unknown | 5 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 25 | 39% |
| Biochemistry, Genetics and Molecular Biology | 14 | 22% |
| Neuroscience | 6 | 9% |
| Engineering | 2 | 3% |
| Chemistry | 2 | 3% |
| Other | 5 | 8% |
| Unknown | 10 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2012.
All research outputs
#17,662,702
of 22,673,450 outputs
Outputs from PLOS ONE
#146,224
of 193,525 outputs
Outputs of similar age
#121,662
of 164,813 outputs
Outputs of similar age from PLOS ONE
#3,067
of 4,082 outputs
Altmetric has tracked 22,673,450 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,525 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,813 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,082 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.