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Graphene quantum dots as autophagy-inducing photodynamic agents

Overview of attention for article published in Biomaterials, October 2012
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

Mentioned by

twitter
1 tweeter
patent
2 patents

Citations

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283 Dimensions

Readers on

mendeley
227 Mendeley
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Title
Graphene quantum dots as autophagy-inducing photodynamic agents
Published in
Biomaterials, October 2012
DOI 10.1016/j.biomaterials.2012.06.060
Pubmed ID
Authors

Zoran M. Markovic, Biljana Z. Ristic, Katarina M. Arsikin, Djordje G. Klisic, Ljubica M. Harhaji-Trajkovic, Biljana M. Todorovic-Markovic, Dejan P. Kepic, Tamara K. Kravic-Stevovic, Svetlana P. Jovanovic, Marina M. Milenkovic, Dusan D. Milivojevic, Vladimir Z. Bumbasirevic, Miroslav D. Dramicanin, Vladimir S. Trajkovic

Abstract

The excellent photoluminescent properties of graphene quantum dots (GQD) makes them suitable candidates for biomedical applications, but their cytotoxicity has not been extensively studied. Here we show that electrochemically produced GQD irradiated with blue light (470 nm, 1W) generate reactive oxygen species, including singlet oxygen, and kill U251 human glioma cells by causing oxidative stress. The cell death induced by photoexcited GQD displayed morphological and/or biochemical characteristics of both apoptosis (phosphatidylserine externalization, caspase activation, DNA fragmentation) and autophagy (formation of autophagic vesicles, LC3-I/LC3-II conversion, degradation of autophagic target p62). Moreover, a genetic inactivation of autophagy-essential LC3B protein partly abrogated the photodynamic cytotoxicity of GQD. These data indicate potential usefulness of GQD in photodynamic therapy, but also raise concerns about their possible toxicity.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 227 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Serbia 2 <1%
United States 2 <1%
China 2 <1%
Belgium 1 <1%
Iran, Islamic Republic of 1 <1%
India 1 <1%
Brazil 1 <1%
Poland 1 <1%
Malaysia 1 <1%
Other 0 0%
Unknown 215 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 67 30%
Researcher 45 20%
Student > Master 37 16%
Student > Postgraduate 13 6%
Professor 10 4%
Other 36 16%
Unknown 19 8%
Readers by discipline Count As %
Chemistry 40 18%
Materials Science 32 14%
Agricultural and Biological Sciences 24 11%
Biochemistry, Genetics and Molecular Biology 22 10%
Physics and Astronomy 19 8%
Other 52 23%
Unknown 38 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2016.
All research outputs
#3,277,015
of 12,238,957 outputs
Outputs from Biomaterials
#2,412
of 7,745 outputs
Outputs of similar age
#30,516
of 118,043 outputs
Outputs of similar age from Biomaterials
#25
of 63 outputs
Altmetric has tracked 12,238,957 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 7,745 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 118,043 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.