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Graphene quantum dots as autophagy-inducing photodynamic agents

Overview of attention for article published in Biomaterials, October 2012
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

Mentioned by

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1 tweeter
patent
2 patents

Citations

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331 Dimensions

Readers on

mendeley
252 Mendeley

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Title
Graphene quantum dots as autophagy-inducing photodynamic agents
Published in
Biomaterials, October 2012
DOI 10.1016/j.biomaterials.2012.06.060
Pubmed ID
22795854
Authors

Zoran M. Markovic, Biljana Z. Ristic, Katarina M. Arsikin, Djordje G. Klisic, Ljubica M. Harhaji-Trajkovic, Biljana M. Todorovic-Markovic, Dejan P. Kepic, Tamara K. Kravic-Stevovic, Svetlana P. Jovanovic, Marina M. Milenkovic, Dusan D. Milivojevic, Vladimir Z. Bumbasirevic, Miroslav D. Dramicanin, Vladimir S. Trajkovic

Abstract

The excellent photoluminescent properties of graphene quantum dots (GQD) makes them suitable candidates for biomedical applications, but their cytotoxicity has not been extensively studied. Here we show that electrochemically produced GQD irradiated with blue light (470 nm, 1W) generate reactive oxygen species, including singlet oxygen, and kill U251 human glioma cells by causing oxidative stress. The cell death induced by photoexcited GQD displayed morphological and/or biochemical characteristics of both apoptosis (phosphatidylserine externalization, caspase activation, DNA fragmentation) and autophagy (formation of autophagic vesicles, LC3-I/LC3-II conversion, degradation of autophagic target p62). Moreover, a genetic inactivation of autophagy-essential LC3B protein partly abrogated the photodynamic cytotoxicity of GQD. These data indicate potential usefulness of GQD in photodynamic therapy, but also raise concerns about their possible toxicity.

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Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 252 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Serbia 2 <1%
China 2 <1%
India 1 <1%
Iran, Islamic Republic of 1 <1%
Brazil 1 <1%
Malaysia 1 <1%
Poland 1 <1%
Belgium 1 <1%
Other 0 0%
Unknown 240 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 67 27%
Researcher 49 19%
Student > Master 38 15%
Student > Postgraduate 14 6%
Student > Doctoral Student 11 4%
Other 45 18%
Unknown 28 11%
Readers by discipline Count As %
Chemistry 45 18%
Materials Science 32 13%
Biochemistry, Genetics and Molecular Biology 24 10%
Agricultural and Biological Sciences 23 9%
Engineering 21 8%
Other 60 24%
Unknown 47 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2016.
All research outputs
#6,913,570
of 22,673,450 outputs
Outputs from Biomaterials
#4,079
of 10,280 outputs
Outputs of similar age
#50,951
of 172,124 outputs
Outputs of similar age from Biomaterials
#75
of 168 outputs
Altmetric has tracked 22,673,450 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 10,280 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,124 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 168 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.

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