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Debate: The slippery slope of surrogate outcomes

Overview of attention for article published in Trials, October 2000
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Debate: The slippery slope of surrogate outcomes
Published in
Trials, October 2000
DOI 10.1186/cvm-1-2-076
Pubmed ID

Ralph B D'Agostino


Surrogate outcomes are frequently used in cardiovascular disease research. A concern is that changes in surrogate markers may not reflect changes in disease outcomes. Two recent clinical trials (Heart and Estrogen/Progestin Replacement Study [HERS], and the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial [ALLHAT]) underscore this problem since their results contradicted what was expected based on the surrogate outcomes. The current regulatory policy to allow new therapies to be introduced onto the market based solely on surrogate outcomes may need to be reviewed.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Colombia 1 3%
Unknown 28 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 20%
Professor 3 10%
Student > Bachelor 3 10%
Student > Postgraduate 3 10%
Student > Ph. D. Student 3 10%
Other 7 23%
Unknown 5 17%
Readers by discipline Count As %
Medicine and Dentistry 13 43%
Biochemistry, Genetics and Molecular Biology 2 7%
Environmental Science 1 3%
Agricultural and Biological Sciences 1 3%
Chemical Engineering 1 3%
Other 4 13%
Unknown 8 27%