↓ Skip to main content

Ageing of enteric neurons: oxidative stress, neurotrophic factors and antioxidant enzymes

Overview of attention for article published in Chemistry Central Journal, August 2012
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

Mentioned by

twitter
1 X user
googleplus
1 Google+ user

Citations

dimensions_citation
16 Dimensions

Readers on

mendeley
32 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Ageing of enteric neurons: oxidative stress, neurotrophic factors and antioxidant enzymes
Published in
Chemistry Central Journal, August 2012
DOI 10.1186/1752-153x-6-80
Pubmed ID
Authors

Kris Korsak, Nazanin F Dolatshad, Ayona T Silva, M Jill Saffrey

Abstract

Ageing is associated with gastrointestinal dysfunction, which can have a major impact on quality of life of the elderly. A number of changes in the innervation of the gut during ageing have been reported, including neuronal loss and degenerative changes. Evidence indicates that reactive oxygen species (ROS) are elevated in ageing enteric neurons, but that neurotrophic factors may reduce generation of neuronal ROS. Two such factors, glial cell line derived neurotrophic factor (GDNF) and neurotrophin-3 (NT-3) have also been found to protect enteric neurons against oxidative stress induced cell death of enteric ganglion cells in vitro. We have investigated the possible roles of neurotrophic factors further, by examining their expression in the gut during ageing, and by analysing their effects on antioxidant enzyme production in cultures of enteric ganglion cells.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 3%
Unknown 31 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 16%
Student > Ph. D. Student 4 13%
Researcher 4 13%
Professor > Associate Professor 4 13%
Student > Doctoral Student 3 9%
Other 6 19%
Unknown 6 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 28%
Neuroscience 6 19%
Medicine and Dentistry 4 13%
Biochemistry, Genetics and Molecular Biology 2 6%
Nursing and Health Professions 1 3%
Other 3 9%
Unknown 7 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2012.
All research outputs
#16,462,378
of 25,986,827 outputs
Outputs from Chemistry Central Journal
#1
of 1 outputs
Outputs of similar age
#110,643
of 180,238 outputs
Outputs of similar age from Chemistry Central Journal
#7
of 22 outputs
Altmetric has tracked 25,986,827 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1 research outputs from this source. They receive a mean Attention Score of 1.5. This one scored the same or higher as 0 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 180,238 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.