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HIV-1 Envelope Resistance to Proteasomal Cleavage: Implications for Vaccine Induced Immune Responses

Overview of attention for article published in PLOS ONE, August 2012
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Title
HIV-1 Envelope Resistance to Proteasomal Cleavage: Implications for Vaccine Induced Immune Responses
Published in
PLOS ONE, August 2012
DOI 10.1371/journal.pone.0042579
Pubmed ID
Authors

Nicholas J. Steers, Silvia Ratto-Kim, Mark S. de Souza, Jeffrey R. Currier, Jerome H. Kim, Nelson L. Michael, Carl R. Alving, Mangala Rao

Abstract

Antigen processing involves many proteolytic enzymes such as proteasomes and cathepsins. The processed antigen is then presented on the cell surface bound to either MHC class I or class II molecules and induces/interacts with antigen-specific CD8+ and CD4+ T-cells, respectively. Preliminary immunological data from the RV144 phase III trial indicated that the immune responses were biased towards the Env antigen with a dominant CD4+ T-cell response.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 34%
Student > Master 5 17%
Student > Ph. D. Student 5 17%
Other 2 7%
Student > Bachelor 2 7%
Other 4 14%
Unknown 1 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 28%
Immunology and Microbiology 6 21%
Medicine and Dentistry 5 17%
Biochemistry, Genetics and Molecular Biology 3 10%
Chemistry 3 10%
Other 2 7%
Unknown 2 7%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2023.
All research outputs
#18,900,960
of 23,420,064 outputs
Outputs from PLOS ONE
#160,616
of 200,414 outputs
Outputs of similar age
#128,945
of 167,544 outputs
Outputs of similar age from PLOS ONE
#3,258
of 4,136 outputs
Altmetric has tracked 23,420,064 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 200,414 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.3. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 167,544 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,136 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.