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Human Endogenous Retrovirus Expression Is Inversely Associated with Chronic Immune Activation in HIV-1 Infection

Overview of attention for article published in PLOS ONE, August 2012
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Title
Human Endogenous Retrovirus Expression Is Inversely Associated with Chronic Immune Activation in HIV-1 Infection
Published in
PLOS ONE, August 2012
DOI 10.1371/journal.pone.0041021
Pubmed ID
Authors

Christopher E. Ormsby, Devi SenGupta, Ravi Tandon, Steven G. Deeks, Jeffrey N. Martin, R. Brad Jones, Mario A. Ostrowski, Keith E. Garrison, Joel A. Vázquez-Pérez, Gustavo Reyes-Terán, Douglas F. Nixon

Abstract

Human endogenous retroviruses (HERV) are remnants of ancestral retroviral infections integrated into the germ line, and constitute approximately 8% of the genome. Several autoimmune disorders, malignancies, and infectious diseases such as HIV-1 are associated with higher HERV expression. The degree to which HERV expression in vivo results in persistent inflammation is not known. We studied the association of immune activation and HERV-K expression in 20 subjects with chronic, untreated progressive HIV-1 infection and 10 HIV-1 negative controls. The mean HERV-K gag and env RNA expression level in the HIV-1 infected cohort was higher than in the control group (p = 0.0003), and was negatively correlated with the frequency of activated CD38+HLA-DR+CD4+ T cells (Rho = -0.61; p = 0.01) and activated CD38+HLA-DR+CD8+ T cells (Rho = -0.51; p = 0.03). Although HIV-infected persons had higher levels of HERV-K RNA expression (as expected), the level of RNA expression was negatively associated with level of T cell activation. The mechanism for this unexpected association remains to be defined.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Brazil 1 2%
Germany 1 2%
Iran, Islamic Republic of 1 2%
India 1 2%
Unknown 60 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 33%
Student > Ph. D. Student 9 14%
Student > Bachelor 8 12%
Student > Master 6 9%
Student > Doctoral Student 3 5%
Other 8 12%
Unknown 10 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 24%
Immunology and Microbiology 14 21%
Biochemistry, Genetics and Molecular Biology 11 17%
Medicine and Dentistry 9 14%
Sports and Recreations 2 3%
Other 3 5%
Unknown 11 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2024.
All research outputs
#19,757,934
of 25,152,132 outputs
Outputs from PLOS ONE
#170,778
of 218,157 outputs
Outputs of similar age
#131,856
of 174,750 outputs
Outputs of similar age from PLOS ONE
#3,130
of 4,150 outputs
Altmetric has tracked 25,152,132 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 218,157 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.7. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
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