@Ella_Maru An amusing consequence is that since naive germline Abs are more conformationally flexible than functional Abs, design with antibody PLMs would lead to decreased stability - exactly the opposite of general PLMs like ESM! Figure from https://t.co
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RT @antibodymap: Local and global rigidification upon affinity maturation https://t.co/ytQ0TmiSzN
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Local and global rigidification upon affinity maturation https://t.co/ytQ0TmiSzN
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RT @FrontMolBioSci: New Research: Local and Global Rigidification Upon Antibody Affinity Maturation https://t.co/0gJEOphrQD #MolBioSci