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Genome-Wide Analysis in Brazilian Xavante Indians Reveals Low Degree of Admixture

Overview of attention for article published in PLOS ONE, August 2012
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Title
Genome-Wide Analysis in Brazilian Xavante Indians Reveals Low Degree of Admixture
Published in
PLOS ONE, August 2012
DOI 10.1371/journal.pone.0042702
Pubmed ID
Authors

Patricia C. Kuhn, Andréa R. V. Russo. Horimoto, José Maurício Sanches, João Paulo B. Vieira Filho, Luciana Franco, Amaury Dal Fabbro, Laercio Joel Franco, Alexandre C. Pereira, Regina S Moises

Abstract

Characterization of population genetic variation and structure can be used as tools for research in human genetics and population isolates are of great interest. The aim of the present study was to characterize the genetic structure of Xavante Indians and compare it with other populations. The Xavante, an indigenous population living in Brazilian Central Plateau, is one of the largest native groups in Brazil. A subset of 53 unrelated subjects was selected from the initial sample of 300 Xavante Indians. Using 86,197 markers, Xavante were compared with all populations of HapMap Phase III and HGDP-CEPH projects and with a Southeast Brazilian population sample to establish its population structure. Principal Components Analysis showed that the Xavante Indians are concentrated in the Amerindian axis near other populations of known Amerindian ancestry such as Karitiana, Pima, Surui and Maya and a low degree of genetic admixture was observed. This is consistent with the historical records of bottlenecks experience and cultural isolation. By calculating pair-wise F(st) statistics we characterized the genetic differentiation between Xavante Indians and representative populations of the HapMap and from HGDP-CEPH project. We found that the genetic differentiation between Xavante Indians and populations of Ameridian, Asian, European, and African ancestry increased progressively. Our results indicate that the Xavante is a population that remained genetically isolated over the past decades and can offer advantages for genome-wide mapping studies of inherited disorders.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 3%
Unknown 37 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 26%
Student > Master 9 24%
Professor > Associate Professor 4 11%
Researcher 4 11%
Student > Doctoral Student 3 8%
Other 7 18%
Unknown 1 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 45%
Biochemistry, Genetics and Molecular Biology 5 13%
Medicine and Dentistry 5 13%
Social Sciences 4 11%
Nursing and Health Professions 1 3%
Other 2 5%
Unknown 4 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2012.
All research outputs
#13,365,440
of 22,673,450 outputs
Outputs from PLOS ONE
#106,382
of 193,525 outputs
Outputs of similar age
#92,689
of 167,363 outputs
Outputs of similar age from PLOS ONE
#2,168
of 4,162 outputs
Altmetric has tracked 22,673,450 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,525 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 167,363 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,162 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.