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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells
|
|---|---|
| Published in |
Journal of Neuroinflammation, August 2012
|
| DOI | 10.1186/1742-2094-9-199 |
| Pubmed ID | |
| Authors |
Elina M Sutinen, Tuula Pirttilä, George Anderson, Antero Salminen, Johanna O Ojala |
| Abstract |
Alzheimer's disease (AD) involves increased accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles as well as neuronal loss in various regions of the neocortex. Neuroinflammation is also present, but its role in AD is not fully understood. We previously showed increased levels of pro-inflammatory cytokine interleukin-18 (IL-18) in different regions of AD brains, where it co-localized with Aβ-plaques, as well as the ability of IL-18 to increase expression of glycogen synthase kinase-3β (GSK-3β) and cyclin dependent kinase 5, involved in hyperphosphorylation of tau-protein. Elevated IL-18 has been detected in several risk conditions for AD, including obesity, type-II diabetes, and cardiovascular diseases as well as in stress. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 50% |
| Spain | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 167 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Unknown | 166 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 34 | 20% |
| Student > Bachelor | 25 | 15% |
| Student > Ph. D. Student | 23 | 14% |
| Student > Master | 18 | 11% |
| Professor | 6 | 4% |
| Other | 27 | 16% |
| Unknown | 34 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 30 | 18% |
| Neuroscience | 30 | 18% |
| Agricultural and Biological Sciences | 27 | 16% |
| Medicine and Dentistry | 18 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 5% |
| Other | 15 | 9% |
| Unknown | 38 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2021.
All research outputs
#2,557,517
of 25,654,806 outputs
Outputs from Journal of Neuroinflammation
#348
of 2,969 outputs
Outputs of similar age
#15,621
of 174,561 outputs
Outputs of similar age from Journal of Neuroinflammation
#4
of 54 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,969 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 174,561 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.