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Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expression in vivo

Overview of attention for article published in Journal of The Royal Society Interface, June 2016
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  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (52nd percentile)

Mentioned by

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5 tweeters

Citations

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6 Dimensions

Readers on

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25 Mendeley
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Title
Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expression in vivo
Published in
Journal of The Royal Society Interface, June 2016
DOI 10.1098/rsif.2016.0337
Pubmed ID
Authors

Eimear B. Dolan, David Tallon, Wing-Yee Cheung, Mitchell B. Schaffler, Oran D. Kennedy, Laoise M. McNamara

Abstract

Bone is often subject to harsh temperatures during orthopaedic procedures resulting in thermally induced bone damage, which may affect the healing response. Postsurgical healing of bone is essential to the success of surgery, therefore, an understanding of the thermally induced responses of bone cells to clinically relevant temperatures in vivo is required. Osteocytes have been shown to be integrally involved in the bone remodelling cascade, via apoptosis, in micro-damage systems. However, it is unknown whether this relationship is similar following thermal damage. Sprague-Dawley rat tibia were exposed to clinically relevant temperatures (47°C or 60°C) to investigate the role of osteocytes in modulating remodelling related factors. Immunohistochemistry was used to quantify osteocyte thermal damage (activated caspase-3). Thermally induced pro-osteoclastogenic genes (Rankl, Opg and M-csf), in addition to genes known to mediate osteoblast and osteoclast differentiation via prostaglandin production (Cox2), vascularization (Vegf) and inflammatory (Il1a) responses, were investigated using gene expression analysis. The results demonstrate that heat-treatment induced significant bone tissue and cellular damage. Pro-osteoclastogenic genes were upregulated depending on the amount of temperature elevation compared with the control. Taken together, the results of this study demonstrate the in vivo effect of thermally induced osteocyte damage on the gene expression profile.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Belgium 1 4%
Unknown 23 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 16%
Researcher 4 16%
Student > Doctoral Student 3 12%
Lecturer 2 8%
Student > Master 2 8%
Other 5 20%
Unknown 5 20%
Readers by discipline Count As %
Medicine and Dentistry 8 32%
Engineering 5 20%
Agricultural and Biological Sciences 2 8%
Sports and Recreations 1 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 0 0%
Unknown 8 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2016.
All research outputs
#3,730,152
of 14,232,146 outputs
Outputs from Journal of The Royal Society Interface
#1,068
of 2,257 outputs
Outputs of similar age
#74,105
of 263,060 outputs
Outputs of similar age from Journal of The Royal Society Interface
#24
of 51 outputs
Altmetric has tracked 14,232,146 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 2,257 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.5. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,060 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.