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Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane

Overview of attention for article published in Cancer Prevention Research, June 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#2 of 1,309)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

news
80 news outlets
twitter
8 tweeters
wikipedia
1 Wikipedia page
googleplus
1 Google+ user
reddit
1 Redditor
video
2 video uploaders

Citations

dimensions_citation
62 Dimensions

Readers on

mendeley
88 Mendeley
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Title
Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane
Published in
Cancer Prevention Research, June 2016
DOI 10.1158/1940-6207.capr-15-0290
Pubmed ID
Authors

Julie E. Bauman, Yan Zang, Malabika Sen, Changyou Li, Lin Wang, Patricia A. Egner, Jed W. Fahey, Daniel P. Normolle, Jennifer R. Grandis, Thomas W. Kensler, Daniel E. Johnson

Abstract

Chronic exposure to carcinogens represents the major risk factor for head and neck squamous cell carcinoma (HNSCC). Beverages derived from broccoli sprout extracts (BSE) that are rich in glucoraphanin and its bioactive metabolite sulforaphane promote detoxication of airborne pollutants in humans. Herein, we investigated the potential chemopreventive activity of sulforaphane using in vitro models of normal and malignant mucosal epithelial cells and an in vivo model of murine oral cancer resulting from the carcinogen 4-nitroquinoline-1-oxide (4NQO). Sulforaphane treatment of Het-1A, a normal mucosal epithelial cell line, and 4 HNSCC cell lines led to dose- and time-dependent induction of NRF2 and the NRF2 target genes NQO1 and GCLC, known mediators of carcinogen detoxication. Sulforaphane also promoted NRF2-independent dephosphorylation/inactivation of pSTAT3, a key oncogenic factor in HNSCC. Compared with vehicle, sulforaphane significantly reduced the incidence and size of 4NQO-induced tongue tumors in mice. A pilot clinical trial in 10 healthy volunteers evaluated the bioavailability and pharmacodynamic activity of three different BSE regimens, based upon urinary sulforaphane metabolites and NQO1 transcripts in buccal scrapings, respectively. Ingestion of sulforaphane-rich BSE demonstrated the greatest, most consistent bioavailability. Mucosal bioactivity, defined as 2-fold or greater upregulation of NQO1 mRNA, was observed in 6 of 9 evaluable participants ingesting glucoraphanin-rich BSE; 3 of 6 ingesting sulforaphane-rich BSE; and 3 of 9 after topical-only exposure to sulforaphane-rich BSE. Together, our findings demonstrate preclinical chemopreventive activity of sulforaphane against carcinogen-induced oral cancer, and support further mechanistic and clinical investigation of sulforaphane as a chemopreventive agent against tobacco-related HNSCC. Cancer Prev Res; 9(7); 1-11. ©2016 AACR.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 88 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 15 17%
Student > Ph. D. Student 14 16%
Researcher 12 14%
Student > Bachelor 9 10%
Student > Doctoral Student 6 7%
Other 7 8%
Unknown 25 28%
Readers by discipline Count As %
Medicine and Dentistry 22 25%
Biochemistry, Genetics and Molecular Biology 10 11%
Agricultural and Biological Sciences 9 10%
Pharmacology, Toxicology and Pharmaceutical Science 7 8%
Nursing and Health Professions 5 6%
Other 8 9%
Unknown 27 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 630. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2022.
All research outputs
#25,244
of 21,423,731 outputs
Outputs from Cancer Prevention Research
#2
of 1,309 outputs
Outputs of similar age
#587
of 277,486 outputs
Outputs of similar age from Cancer Prevention Research
#2
of 23 outputs
Altmetric has tracked 21,423,731 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,309 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,486 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.