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Extracellular ATP activates NFAT-dependent gene expression in neuronal PC12 cells via P2X receptors

Overview of attention for article published in BMC Neuroscience, January 2011
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Title
Extracellular ATP activates NFAT-dependent gene expression in neuronal PC12 cells via P2X receptors
Published in
BMC Neuroscience, January 2011
DOI 10.1186/1471-2202-12-90
Pubmed ID
Authors

Prabin Prasai, Georgios C Stefos, Walter Becker

Abstract

Treatment of neuronal PC12 cells with ATP induces depolarisation and increases intracellular calcium levels via purinergic receptors. In many cell types, sustained elevation of intracellular calcium levels cause changes in gene expression via activation of the transcription factor NFAT (nuclear factor of activated T cells). We have therefore characterised the signalling pathway by which ATP regulates NFAT-dependent gene expression in PC12 cells.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 26%
Researcher 5 26%
Professor > Associate Professor 4 21%
Professor 1 5%
Student > Master 1 5%
Other 2 11%
Unknown 1 5%
Readers by discipline Count As %
Medicine and Dentistry 6 32%
Agricultural and Biological Sciences 5 26%
Neuroscience 3 16%
Psychology 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Other 1 5%
Unknown 2 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2012.
All research outputs
#10,994,827
of 12,372,276 outputs
Outputs from BMC Neuroscience
#818
of 993 outputs
Outputs of similar age
#107,774
of 126,034 outputs
Outputs of similar age from BMC Neuroscience
#19
of 24 outputs
Altmetric has tracked 12,372,276 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 993 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 126,034 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.