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X Demographics
Mendeley readers
Attention Score in Context
| Title |
MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation
|
|---|---|
| Published in |
Nature Communications, June 2016
|
| DOI | 10.1038/ncomms11807 |
| Pubmed ID | |
| Authors |
Anton Shostak, Bianca Ruppert, Nati Ha, Philipp Bruns, Umut H. Toprak, Roland Eils, Matthias Schlesner, Axel Diernfellner, Michael Brunner |
| Abstract |
The circadian clock and the cell cycle are major cellular systems that organize global physiology in temporal fashion. It seems conceivable that the potentially conflicting programs are coordinated. We show here that overexpression of MYC in U2OS cells attenuates the clock and conversely promotes cell proliferation while downregulation of MYC strengthens the clock and reduces proliferation. Inhibition of the circadian clock is crucially dependent on the formation of repressive complexes of MYC with MIZ1 and subsequent downregulation of the core clock genes BMAL1 (ARNTL), CLOCK and NPAS2. We show furthermore that BMAL1 expression levels correlate inversely with MYC levels in 102 human lymphomas. Our data suggest that MYC acts as a master coordinator that inversely modulates the impact of cell cycle and circadian clock on gene expression. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | <1% |
| Denmark | 1 | <1% |
| France | 1 | <1% |
| Unknown | 118 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 27% |
| Researcher | 17 | 14% |
| Student > Bachelor | 13 | 11% |
| Student > Master | 11 | 9% |
| Other | 7 | 6% |
| Other | 19 | 16% |
| Unknown | 21 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 54 | 45% |
| Agricultural and Biological Sciences | 20 | 17% |
| Medicine and Dentistry | 8 | 7% |
| Mathematics | 2 | 2% |
| Engineering | 2 | 2% |
| Other | 11 | 9% |
| Unknown | 24 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2016.
All research outputs
#14,856,117
of 22,879,161 outputs
Outputs from Nature Communications
#41,308
of 47,131 outputs
Outputs of similar age
#212,945
of 352,727 outputs
Outputs of similar age from Nature Communications
#678
of 796 outputs
Altmetric has tracked 22,879,161 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 47,131 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.8. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,727 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 796 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.