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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Molecular mechanisms of regulation of Toll-like receptor signaling
|
|---|---|
| Published in |
Journal of Leukocyte Biology, June 2016
|
| DOI | 10.1189/jlb.2mr0316-117rr |
| Pubmed ID | |
| Authors |
Cynthia A Leifer, Andrei E Medvedev |
| Abstract |
TLRs play a critical role in the detection of microbes and endogenous "alarmins" to initiate host defense, yet they can also contribute to the development and progression of inflammatory and autoimmune diseases. To avoid pathogenic inflammation, TLR signaling is subject to multilayer regulatory control mechanisms, including cooperation with coreceptors, post-translational modifications, cleavage, cellular trafficking, and interactions with negative regulators. Nucleic acid-sensing TLRs are particularly interesting in this regard, as they can both recognize host-derived structures and require internalization of their ligand as a result of intracellular sequestration of the nucleic acid-sensing TLRs. This review summarizes the regulatory mechanisms of TLRs, including regulation of their access to ligands, receptor folding, intracellular trafficking, and post-translational modifications, as well as how altered control mechanism could contribute to inflammatory and autoimmune disorders. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 222 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Germany | 1 | <1% |
| Australia | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 218 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 17% |
| Researcher | 36 | 16% |
| Student > Master | 33 | 15% |
| Student > Bachelor | 31 | 14% |
| Student > Doctoral Student | 14 | 6% |
| Other | 24 | 11% |
| Unknown | 46 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 48 | 22% |
| Immunology and Microbiology | 38 | 17% |
| Agricultural and Biological Sciences | 37 | 17% |
| Medicine and Dentistry | 18 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 4% |
| Other | 17 | 8% |
| Unknown | 56 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2019.
All research outputs
#15,379,002
of 22,879,161 outputs
Outputs from Journal of Leukocyte Biology
#3,087
of 4,002 outputs
Outputs of similar age
#223,171
of 352,727 outputs
Outputs of similar age from Journal of Leukocyte Biology
#36
of 66 outputs
Altmetric has tracked 22,879,161 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,002 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,727 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.