Title |
IRF5 gene polymorphisms in melanoma
|
---|---|
Published in |
Journal of Translational Medicine, August 2012
|
DOI | 10.1186/1479-5876-10-170 |
Pubmed ID | |
Authors |
Lorenzo Uccellini, Valeria De Giorgi, Yingdong Zhao, Barbara Tumaini, Narnygerel Erdenebileg, Mark E Dudley, Sara Tomei, Davide Bedognetti, Maria Libera Ascierto, Qiuzhen Liu, Richard Simon, Leah Kottyan, Kenneth M Kaufman, John B Harley, Ena Wang, Steven A Rosenberg, Francesco M Marincola |
Abstract |
Interferon regulatory factor (IRF)-5 is a transcription factor involved in type I interferon signaling whose germ line variants have been associated with autoimmune pathogenesis. Since relationships have been observed between development of autoimmunity and responsiveness of melanoma to several types of immunotherapy, we tested whether polymorphisms of IRF5 are associated with responsiveness of melanoma to adoptive therapy with tumor infiltrating lymphocytes (TILs). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Qatar | 1 | 5% |
Unknown | 20 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 29% |
Student > Ph. D. Student | 4 | 19% |
Student > Bachelor | 2 | 10% |
Student > Master | 2 | 10% |
Professor | 1 | 5% |
Other | 2 | 10% |
Unknown | 4 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 5 | 24% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Medicine and Dentistry | 2 | 10% |
Nursing and Health Professions | 1 | 5% |
Psychology | 1 | 5% |
Other | 3 | 14% |
Unknown | 7 | 33% |