Title |
Toxoplasmic encephalitis: role of Human Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome
|
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Published in |
Brazilian Journal of Infectious Diseases, January 2016
|
DOI | 10.1016/j.bjid.2015.10.010 |
Pubmed ID | |
Authors |
Maria de Lourdes Rodrigues, Neifi Hassam Deghaide, José Fernando Figueiredo, Marcelo Bezerra de Menezes, Ana Lúcia Demarco, Eduardo Donadi, Ana Paula Fernandes |
Abstract |
The frequency of Human Leucocyte Antigens/alleles associated with rapid progression from Human Immunodeficiency Virus infection to Acquired Immunodeficiency Syndrome was evaluated in Brazilian patients with Acquired Immunodeficiency Syndrome with and without Toxoplasmic Encephalitis. 114 patients with Acquired Immunodeficiency Syndrome (41 with Toxoplasmic Encephalitis, 43 with anti-Toxoplasma gondii antibodies, without Toxoplasmic Eencephalitis, and 30 without anti-Toxoplasma gondii antibodies circulating and without Toxoplasmic Encephalitis) were studied. Human Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome, particularly HLA-B35, -DR3, and -DR1 allele group, were significantly less represented in patients with Toxoplasmic Encephalitis and Acquired Immunodeficiency Syndrome. The presence of these Human Leucocyte Antigens/Alleles that predispose to Acquired Immunodeficiency Syndrome progression was associated with resistance to Toxoplasmic Encephalitis among Human Immunodeficiency Virus-1 carriers. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 5% |
Brazil | 1 | 5% |
Unknown | 17 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 42% |
Other | 2 | 11% |
Student > Bachelor | 2 | 11% |
Student > Postgraduate | 2 | 11% |
Student > Ph. D. Student | 1 | 5% |
Other | 3 | 16% |
Unknown | 1 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 37% |
Agricultural and Biological Sciences | 4 | 21% |
Veterinary Science and Veterinary Medicine | 1 | 5% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Unspecified | 1 | 5% |
Other | 2 | 11% |
Unknown | 3 | 16% |