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Identification of Phenolic Compounds from Seed Coats of Differently Colored European Varieties of Pea (Pisum sativumL.) and Characterization of Their Antioxidant and In Vitro Anticancer Activities

Overview of attention for article published in Nutrition and Cancer, June 2016
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Title
Identification of Phenolic Compounds from Seed Coats of Differently Colored European Varieties of Pea (Pisum sativumL.) and Characterization of Their Antioxidant and In Vitro Anticancer Activities
Published in
Nutrition and Cancer, June 2016
DOI 10.1080/01635581.2016.1190019
Pubmed ID
Authors

Nemanja S. Stanisavljević, Marija D. Ilić, Ivana Z. Matić, Živko S. Jovanović, Tihomir Čupić, Dragana Č. Dabić, Maja M. Natić, Živoslav Lj. Tešić

Abstract

To date little has been done on identification of major phenolic compounds responsible for anticancer and antioxidant properties of pea (Pisum sativum L.) seed coat extracts. In the present study, phenolic profile of the seed coat extracts from 10 differently colored European varieties has been determined using ultrahigh-performance liquid chromatography-linear trap quadrupole orbitrap mass spectrometer technique. Extracts of dark colored varieties with high total phenolic content (up to 46.56 mg GAE/g) exhibited strong antioxidant activities (measured by 2,2-diphenyl-1-picrylhydrazyl or DPPH assay, and ferric ion reducing and ferrous ion chelating capacity assays) which could be attributed to presence of gallic acid, epigallocatechin, naringenin, and apigenin. The aqueous extracts of dark colored varieties exert concentration-dependent cytotoxic effects on all tested malignant cell lines (human colon adenocarcinoma LS174, human breast carcinoma MDA-MB-453, human lung carcinoma A594, and myelogenous leukemia K562). Correlation analysis revealed that intensities of cytotoxic activity of the extracts strongly correlated with contents of epigallocatechin and luteolin. Cell cycle analysis on LS174 cells in the presence of caspase-3 inhibitor points out that extracts may activate other cell death modalities besides caspase-3-dependent apoptosis. The study provides evidence that seed coat extracts of dark colored pea varieties might be used as potential cancer-chemopreventive and complementary agents in cancer therapy.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 49 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 20%
Student > Master 7 14%
Student > Bachelor 5 10%
Student > Doctoral Student 5 10%
Researcher 5 10%
Other 7 14%
Unknown 10 20%
Readers by discipline Count As %
Chemistry 8 16%
Biochemistry, Genetics and Molecular Biology 6 12%
Agricultural and Biological Sciences 6 12%
Nursing and Health Professions 4 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Other 9 18%
Unknown 13 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2016.
All research outputs
#10,037,357
of 12,544,958 outputs
Outputs from Nutrition and Cancer
#1,066
of 1,324 outputs
Outputs of similar age
#181,523
of 260,072 outputs
Outputs of similar age from Nutrition and Cancer
#20
of 39 outputs
Altmetric has tracked 12,544,958 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,324 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,072 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.