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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Deep Sequencing Reveals Novel MicroRNAs and Regulation of MicroRNA Expression during Cell Senescence
|
|---|---|
| Published in |
PLOS ONE, May 2011
|
| DOI | 10.1371/journal.pone.0020509 |
| Pubmed ID | |
| Authors |
Joseph M. Dhahbi, Hani Atamna, Dario Boffelli, Wendy Magis, Stephen R. Spindler, David I. K. Martin |
| Abstract |
In cell senescence, cultured cells cease proliferating and acquire aberrant gene expression patterns. MicroRNAs (miRNAs) modulate gene expression through translational repression or mRNA degradation and have been implicated in senescence. We used deep sequencing to carry out a comprehensive survey of miRNA expression and involvement in cell senescence. Informatic analysis of small RNA sequence datasets from young and senescent IMR90 human fibroblasts identifies many miRNAs that are regulated (either up or down) with cell senescence. Comparison with mRNA expression profiles reveals potential mRNA targets of these senescence-regulated miRNAs. The target mRNAs are enriched for genes involved in biological processes associated with cell senescence. This result greatly extends existing information on the role of miRNAs in cell senescence and is consistent with miRNAs having a causal role in the process. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Central African Republic | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 2% |
| Germany | 2 | 2% |
| Denmark | 2 | 2% |
| Brazil | 2 | 2% |
| Austria | 1 | <1% |
| Unknown | 117 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 36 | 28% |
| Student > Ph. D. Student | 33 | 26% |
| Student > Master | 13 | 10% |
| Professor > Associate Professor | 9 | 7% |
| Professor | 5 | 4% |
| Other | 17 | 13% |
| Unknown | 14 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 69 | 54% |
| Biochemistry, Genetics and Molecular Biology | 21 | 17% |
| Medicine and Dentistry | 10 | 8% |
| Veterinary Science and Veterinary Medicine | 3 | 2% |
| Computer Science | 2 | 2% |
| Other | 8 | 6% |
| Unknown | 14 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2012.
All research outputs
#18,313,878
of 22,675,759 outputs
Outputs from PLOS ONE
#153,821
of 193,562 outputs
Outputs of similar age
#95,895
of 112,117 outputs
Outputs of similar age from PLOS ONE
#1,400
of 1,685 outputs
Altmetric has tracked 22,675,759 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,562 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 112,117 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,685 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.