Title |
Single-protein nanomechanical mass spectrometry in real time
|
---|---|
Published in |
Nature Nanotechnology, August 2012
|
DOI | 10.1038/nnano.2012.119 |
Pubmed ID | |
Authors |
M. S. Hanay, S. Kelber, A. K. Naik, D. Chi, S. Hentz, E. C. Bullard, E. Colinet, L. Duraffourg, M. L. Roukes |
Abstract |
Nanoelectromechanical systems (NEMS) resonators can detect mass with exceptional sensitivity. Previously, mass spectra from several hundred adsorption events were assembled in NEMS-based mass spectrometry using statistical analysis. Here, we report the first realization of single-molecule NEMS-based mass spectrometry in real time. As each molecule in the sample adsorbs on the resonator, its mass and position of adsorption are determined by continuously tracking two driven vibrational modes of the device. We demonstrate the potential of multimode NEMS-based mass spectrometry by analysing IgM antibody complexes in real time. NEMS-based mass spectrometry is a unique and promising new form of mass spectrometry: it can resolve neutral species, provide a resolving power that increases markedly for very large masses, and allow the acquisition of spectra, molecule-by-molecule, in real time. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 22% |
United States | 3 | 17% |
Spain | 2 | 11% |
Italy | 1 | 6% |
Turkey | 1 | 6% |
Myanmar | 1 | 6% |
Germany | 1 | 6% |
Unknown | 5 | 28% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 13 | 72% |
Scientists | 3 | 17% |
Science communicators (journalists, bloggers, editors) | 1 | 6% |
Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 8 | 2% |
France | 3 | <1% |
Canada | 3 | <1% |
Japan | 2 | <1% |
Italy | 1 | <1% |
Brazil | 1 | <1% |
Germany | 1 | <1% |
United Kingdom | 1 | <1% |
Peru | 1 | <1% |
Other | 5 | 1% |
Unknown | 344 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 123 | 33% |
Researcher | 76 | 21% |
Student > Master | 39 | 11% |
Student > Doctoral Student | 15 | 4% |
Student > Bachelor | 14 | 4% |
Other | 40 | 11% |
Unknown | 63 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 98 | 26% |
Physics and Astronomy | 87 | 24% |
Chemistry | 39 | 11% |
Agricultural and Biological Sciences | 37 | 10% |
Materials Science | 17 | 5% |
Other | 27 | 7% |
Unknown | 65 | 18% |