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Screening for Novel LRRK2 Inhibitors Using a High-Throughput TR-FRET Cellular Assay for LRRK2 Ser935 Phosphorylation

Overview of attention for article published in PLOS ONE, August 2012
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Title
Screening for Novel LRRK2 Inhibitors Using a High-Throughput TR-FRET Cellular Assay for LRRK2 Ser935 Phosphorylation
Published in
PLOS ONE, August 2012
DOI 10.1371/journal.pone.0043580
Pubmed ID
Authors

Spencer B. Hermanson, Coby B. Carlson, Steven M. Riddle, Jing Zhao, Kurt W. Vogel, R. Jeremy Nichols, Kun Bi

Abstract

Mutations in the leucine-rich repeat kinase-2 (LRRK2) have been linked to Parkinson's disease. Recent studies show that inhibition of LRRK2 kinase activity decreased the level of phosphorylation at its own Ser910 and Ser935, indicating that these sites are prime targets for cellular readouts of LRRK2 inhibition.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 69 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 31%
Student > Ph. D. Student 15 21%
Student > Bachelor 9 13%
Student > Master 5 7%
Other 5 7%
Other 7 10%
Unknown 7 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 24%
Biochemistry, Genetics and Molecular Biology 11 16%
Chemistry 11 16%
Medicine and Dentistry 8 11%
Neuroscience 6 9%
Other 7 10%
Unknown 10 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 December 2012.
All research outputs
#18,313,878
of 22,675,759 outputs
Outputs from PLOS ONE
#153,821
of 193,562 outputs
Outputs of similar age
#130,374
of 170,196 outputs
Outputs of similar age from PLOS ONE
#3,421
of 4,362 outputs
Altmetric has tracked 22,675,759 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,562 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,196 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,362 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.