Title |
Telomere Dynamics and Homeostasis in a Transmissible Cancer
|
---|---|
Published in |
PLOS ONE, August 2012
|
DOI | 10.1371/journal.pone.0044085 |
Pubmed ID | |
Authors |
Beata Ujvari, Anne-Maree Pearse, Robyn Taylor, Stephen Pyecroft, Cassandra Flanagan, Sara Gombert, Anthony T. Papenfuss, Thomas Madsen, Katherine Belov |
Abstract |
Devil Facial Tumour Disease (DFTD) is a unique clonal cancer that threatens the world's largest carnivorous marsupial, the Tasmanian devil (Sarcophilus harrisii) with extinction. This transmissible cancer is passed between individual devils by cell implantation during social interactions. The tumour arose in a Schwann cell of a single devil over 15 years ago and since then has expanded clonally, without showing signs of replicative senescence; in stark contrast to a somatic cell that displays a finite capacity for replication, known as the "Hayflick limit". |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 17% |
Unknown | 5 | 83% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 5 | 83% |
Members of the public | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
United States | 1 | 2% |
Romania | 1 | 2% |
Unknown | 53 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 27% |
Student > Master | 12 | 21% |
Student > Ph. D. Student | 6 | 11% |
Student > Postgraduate | 6 | 11% |
Student > Bachelor | 5 | 9% |
Other | 7 | 13% |
Unknown | 5 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 28 | 50% |
Immunology and Microbiology | 7 | 13% |
Biochemistry, Genetics and Molecular Biology | 5 | 9% |
Veterinary Science and Veterinary Medicine | 3 | 5% |
Environmental Science | 2 | 4% |
Other | 5 | 9% |
Unknown | 6 | 11% |