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Conformational stability of digestion-resistant peptides of peanut conglutins reveals the molecular basis of their allergenicity

Overview of attention for article published in Scientific Reports, July 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Mentioned by

blogs
1 blog
twitter
1 tweeter

Citations

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46 Dimensions

Readers on

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53 Mendeley
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Title
Conformational stability of digestion-resistant peptides of peanut conglutins reveals the molecular basis of their allergenicity
Published in
Scientific Reports, July 2016
DOI 10.1038/srep29249
Pubmed ID
Authors

Danijela Apostolovic, Dragana Stanic-Vucinic, Harmen H. J. de Jongh, Govardus A. H. de Jong, Jelena Mihailovic, Jelena Radosavljevic, Milica Radibratovic, Julie A. Nordlee, Joseph L. Baumert, Milos Milcic, Steve L. Taylor, Nuria Garrido Clua, Tanja Cirkovic Velickovic, Stef J. Koppelman

Abstract

Conglutins represent the major peanut allergens and are renowned for their resistance to gastro-intestinal digestion. Our aim was to characterize the digestion-resistant peptides (DRPs) of conglutins by biochemical and biophysical methods followed by a molecular dynamics simulation in order to better understand the molecular basis of food protein allergenicity. We have mapped proteolysis sites at the N- and C-termini and at a limited internal segment, while other potential proteolysis sites remained unaffected. Molecular dynamics simulation showed that proteolysis only occurred in the vibrant regions of the proteins. DRPs appeared to be conformationally stable as intact conglutins. Also, the overall secondary structure and IgE-binding potency of DRPs was comparable to that of intact conglutins. The stability of conglutins toward gastro-intestinal digestion, combined with the conformational stability of the resulting DRPs provide conditions for optimal exposure to the intestinal immune system, providing an explanation for the extraordinary allergenicity of peanut conglutins.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 53 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 30%
Researcher 7 13%
Professor > Associate Professor 6 11%
Student > Master 6 11%
Other 3 6%
Other 9 17%
Unknown 6 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 32%
Biochemistry, Genetics and Molecular Biology 10 19%
Chemistry 6 11%
Immunology and Microbiology 3 6%
Medicine and Dentistry 3 6%
Other 3 6%
Unknown 11 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2021.
All research outputs
#2,957,255
of 18,203,597 outputs
Outputs from Scientific Reports
#23,339
of 98,380 outputs
Outputs of similar age
#51,518
of 268,409 outputs
Outputs of similar age from Scientific Reports
#704
of 3,073 outputs
Altmetric has tracked 18,203,597 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,380 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.8. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,409 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 3,073 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.