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Infectivity of Plasmodium falciparum in Malaria-Naive Individuals Is Related to Knob Expression and Cytoadherence of the Parasite

Overview of attention for article published in Infection and Immunity, July 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

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6 tweeters

Citations

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7 Dimensions

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26 Mendeley
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Title
Infectivity of Plasmodium falciparum in Malaria-Naive Individuals Is Related to Knob Expression and Cytoadherence of the Parasite
Published in
Infection and Immunity, July 2016
DOI 10.1128/iai.00414-16
Pubmed ID
Authors

Danielle I. Stanisic, John Gerrard, James Fink, Paul M. Griffin, Xue Q. Liu, Lana Sundac, Silvana Sekuloski, Ingrid B. Rodriguez, Jolien Pingnet, Yuedong Yang, Yaoqi Zhou, Katharine R. Trenholme, Claire Y. T. Wang, Hazel Hackett, Jo-Anne A. Chan, Christine Langer, Eric Hanssen, Stephen L. Hoffman, James G. Beeson, James S. McCarthy, Michael F. Good

Abstract

Plasmodium falciparum is the most virulent human malaria parasite due to its ability to cytoadhere in the microvasculature. Non-human primate studies demonstrated a relationship between knob expression, cytoadherence and infectivity. This has not been examined in humans. Cultured clinical-grade P. falciparum parasites (NF54, 7G8 and 3D7B) and ex vivo-derived cell banks were characterised. Knob and KAHRP expression, CD36 adhesion and antibody recognition of parasitised erythrocytes (PE) were evaluated. Parasites from the cell banks were administered to malaria-naive human volunteers to explore infectivity. For the NF54 and 3D7B cell banks, blood was collected from the study participants for in vitro characterisation. All parasites were infective in vivo However, infectivity of NF54 was dramatically reduced. In vitro characterisation revealed that unlike other cell bank parasites, NF54 PE lacked knobs and did not cytoadhere. Recognition of NF54 PE by immune sera was observed, suggesting PfEMP1 expression. Subsequent recovery of knob-expression and CD36-mediated adhesion was observed in PE derived from participants infected with NF54. Knobless cell bank parasites have a dramatic reduction in their infectivity and ability to adhere to CD36. Subsequent infection of malaria-naïve volunteers restores knob-expression and CD36-mediated cytoadherence, thereby showing that the human environment can modulate virulence.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 4%
Unknown 25 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 19%
Student > Master 5 19%
Student > Bachelor 4 15%
Researcher 4 15%
Unspecified 3 12%
Other 5 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 27%
Unspecified 5 19%
Medicine and Dentistry 4 15%
Agricultural and Biological Sciences 4 15%
Immunology and Microbiology 3 12%
Other 3 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2017.
All research outputs
#6,321,432
of 12,359,213 outputs
Outputs from Infection and Immunity
#3,889
of 5,688 outputs
Outputs of similar age
#94,741
of 264,308 outputs
Outputs of similar age from Infection and Immunity
#26
of 78 outputs
Altmetric has tracked 12,359,213 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,688 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,308 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.