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Management of diabetes mellitus in individuals with chronic kidney disease: therapeutic perspectives and glycemic control

Overview of attention for article published in Clinics, January 2016
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Title
Management of diabetes mellitus in individuals with chronic kidney disease: therapeutic perspectives and glycemic control
Published in
Clinics, January 2016
DOI 10.6061/clinics/2016(01)08
Pubmed ID
Authors

CC Betônico, SM Titan, ML Correa-Giannella, M Nery, M Queiroz

Abstract

The purpose of this study was to evaluate the therapeutic options for diabetes treatment and their potential side effects, in addition to analyzing the risks and benefits of tight glycemic control in patients with diabetic kidney disease. For this review, a search was performed using several pre-defined keyword combinations and their equivalents: "diabetes kidney disease" and "renal failure" in combination with "diabetes treatment" and "oral antidiabetic drugs" or "oral hypoglycemic agents." The search was performed in PubMed, Endocrine Abstracts and the Cochrane Library from January 1980 up to January 2015. Diabetes treatment in patients with diabetic kidney disease is challenging, in part because of progression of renal failure-related changes in insulin signaling, glucose transport and metabolism, favoring both hyperglycemic peaks and hypoglycemia. Additionally, the decline in renal function impairs the clearance and metabolism of antidiabetic agents and insulin, frequently requiring reassessment of prescriptions. The management of hyperglycemia in patients with diabetic kidney disease is even more difficult, requiring adjustment of antidiabetic agents and insulin doses. The health team responsible for the follow-up of these patients should be vigilant and prepared to make such changes; however, unfortunately, there are few guidelines addressing the nuances of the management of this specific population.

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Mendeley readers

The data shown below were compiled from readership statistics for 221 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 <1%
Unknown 220 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 72 33%
Student > Master 32 14%
Student > Postgraduate 17 8%
Researcher 10 5%
Other 9 4%
Other 27 12%
Unknown 54 24%
Readers by discipline Count As %
Medicine and Dentistry 71 32%
Pharmacology, Toxicology and Pharmaceutical Science 56 25%
Nursing and Health Professions 13 6%
Biochemistry, Genetics and Molecular Biology 8 4%
Agricultural and Biological Sciences 6 3%
Other 9 4%
Unknown 58 26%