↓ Skip to main content

Graft versus Host Disease in the Bone Marrow, Liver and Thymus Humanized Mouse Model

Overview of attention for article published in PLOS ONE, September 2012
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

news
1 news outlet
twitter
1 X user

Citations

dimensions_citation
129 Dimensions

Readers on

mendeley
122 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Graft versus Host Disease in the Bone Marrow, Liver and Thymus Humanized Mouse Model
Published in
PLOS ONE, September 2012
DOI 10.1371/journal.pone.0044664
Pubmed ID
Authors

Matthew B. Greenblatt, Vladimir Vbranac, Trevor Tivey, Kelly Tsang, Andrew M. Tager, Antonios O. Aliprantis

Abstract

Mice bearing a "humanized" immune system are valuable tools to experimentally manipulate human cells in vivo and facilitate disease models not normally possible in laboratory animals. Here we describe a form of GVHD that develops in NOD/SCID mice reconstituted with human fetal bone marrow, liver and thymus (NS BLT mice). The skin, lungs, gastrointestinal tract and parotid glands are affected with progressive inflammation and sclerosis. Although all mice showed involvement of at least one organ site, the incidence of overt clinical disease was approximately 35% by 22 weeks after reconstitution. The use of hosts lacking the IL2 common gamma chain (NOD/SCID/γc(-/-)) delayed the onset of disease, but ultimately did not affect incidence. Genetic analysis revealed that particular donor HLA class I alleles influenced the risk for the development of GVHD. At a cellular level, GVHD is associated with the infiltration of human CD4+ T cells into the skin and a shift towards Th1 cytokine production. GVHD also induced a mixed M1/M2 polarization phenotype in a dermal murine CD11b+, MHC class II+ macrophage population. The presence of xenogenic GVHD in BLT mice both presents a major obstacle in the use of humanized mice and an opportunity to conduct preclinical studies on GVHD in a humanized model.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 122 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Netherlands 1 <1%
France 1 <1%
Italy 1 <1%
Unknown 117 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 27 22%
Student > Ph. D. Student 24 20%
Student > Doctoral Student 10 8%
Student > Bachelor 9 7%
Other 8 7%
Other 22 18%
Unknown 22 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 25%
Medicine and Dentistry 28 23%
Immunology and Microbiology 13 11%
Biochemistry, Genetics and Molecular Biology 12 10%
Pharmacology, Toxicology and Pharmaceutical Science 5 4%
Other 8 7%
Unknown 26 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2023.
All research outputs
#2,981,791
of 23,796,227 outputs
Outputs from PLOS ONE
#38,483
of 203,224 outputs
Outputs of similar age
#20,256
of 170,593 outputs
Outputs of similar age from PLOS ONE
#660
of 4,381 outputs
Altmetric has tracked 23,796,227 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 203,224 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.4. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,593 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 4,381 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.