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A Novel In Vivo siRNA Delivery System Specifically Targeting Liver Cells for Protection of ConA-Induced Fulminant Hepatitis

Overview of attention for article published in PLOS ONE, September 2012
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Title
A Novel In Vivo siRNA Delivery System Specifically Targeting Liver Cells for Protection of ConA-Induced Fulminant Hepatitis
Published in
PLOS ONE, September 2012
DOI 10.1371/journal.pone.0044138
Pubmed ID
Authors

Nan Jiang, Xusheng Zhang, Xiufen Zheng, Di Chen, Kingsun Siu, Hongmei Wang, Thomas E. Ichim, Douglas Quan, Vivian McAlister, Guihua Chen, Wei-Ping Min

Abstract

Fulminant hepatitis progresses to acute liver failure (ALF) when the extent of hepatocyte death exceeds the liver's regenerative capacity. Although small interfering RNA (siRNA) appears promising in animal models of hepatitis, the approach is limited by drawbacks associated with systemic administration of siRNA. The aim of this study is to develop a hepatocyte-specific delivery system of siRNA for treatment of fulminant hepatitis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
Netherlands 1 2%
United States 1 2%
Unknown 47 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 28%
Student > Ph. D. Student 14 28%
Student > Bachelor 6 12%
Other 4 8%
Professor 3 6%
Other 7 14%
Unknown 2 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 24%
Chemistry 10 20%
Biochemistry, Genetics and Molecular Biology 7 14%
Engineering 4 8%
Medicine and Dentistry 4 8%
Other 8 16%
Unknown 5 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2022.
All research outputs
#13,206,623
of 23,377,816 outputs
Outputs from PLOS ONE
#105,433
of 199,897 outputs
Outputs of similar age
#90,289
of 170,441 outputs
Outputs of similar age from PLOS ONE
#2,141
of 4,383 outputs
Altmetric has tracked 23,377,816 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 199,897 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.3. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,441 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,383 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.