Title |
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
|
---|---|
Published in |
Nature Reviews Neuroscience, September 2012
|
DOI | 10.1038/nrn3346 |
Pubmed ID | |
Authors |
John F. Cryan, Timothy G. Dinan |
Abstract |
Recent years have witnessed the rise of the gut microbiota as a major topic of research interest in biology. Studies are revealing how variations and changes in the composition of the gut microbiota influence normal physiology and contribute to diseases ranging from inflammation to obesity. Accumulating data now indicate that the gut microbiota also communicates with the CNS--possibly through neural, endocrine and immune pathways--and thereby influences brain function and behaviour. Studies in germ-free animals and in animals exposed to pathogenic bacterial infections, probiotic bacteria or antibiotic drugs suggest a role for the gut microbiota in the regulation of anxiety, mood, cognition and pain. Thus, the emerging concept of a microbiota-gut-brain axis suggests that modulation of the gut microbiota may be a tractable strategy for developing novel therapeutics for complex CNS disorders. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 31 | 19% |
United Kingdom | 16 | 10% |
Australia | 16 | 10% |
Canada | 8 | 5% |
Spain | 5 | 3% |
Ireland | 4 | 2% |
Denmark | 3 | 2% |
Norway | 3 | 2% |
Japan | 2 | 1% |
Other | 8 | 5% |
Unknown | 65 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 110 | 68% |
Scientists | 31 | 19% |
Practitioners (doctors, other healthcare professionals) | 14 | 9% |
Science communicators (journalists, bloggers, editors) | 6 | 4% |
Mendeley readers
Geographical breakdown
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---|---|---|
United States | 51 | 1% |
United Kingdom | 12 | <1% |
Switzerland | 9 | <1% |
Spain | 8 | <1% |
Brazil | 8 | <1% |
Portugal | 6 | <1% |
Italy | 5 | <1% |
Canada | 5 | <1% |
France | 5 | <1% |
Other | 54 | 1% |
Unknown | 4701 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 817 | 17% |
Student > Ph. D. Student | 750 | 15% |
Student > Master | 685 | 14% |
Researcher | 656 | 13% |
Student > Doctoral Student | 247 | 5% |
Other | 754 | 16% |
Unknown | 955 | 20% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 634 | 13% |
Biochemistry, Genetics and Molecular Biology | 505 | 10% |
Neuroscience | 400 | 8% |
Psychology | 250 | 5% |
Other | 872 | 18% |
Unknown | 1124 | 23% |