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Doppler resistive index to reflect regulation of renal vascular tone during sepsis and acute kidney injury

Overview of attention for article published in Critical Care, September 2012
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Title
Doppler resistive index to reflect regulation of renal vascular tone during sepsis and acute kidney injury
Published in
Critical Care, September 2012
DOI 10.1186/cc11517
Pubmed ID
Authors

Antoine Dewitte, Julien Coquin, Bertrand Meyssignac, Olivier Joannès-Boyau, Catherine Fleureau, Hadrien Roze, Jean Ripoche, Gérard Janvier, Christian Combe, Alexandre Ouattara

Abstract

ABSTRACT: INTRODUCTION: Renal resistive index (RI), determined by Doppler ultrasonography, directly reveals and quantifies modifications in renal vascular resistance. The aim of this study was to evaluate if mean arterial pressure (MAP) is determinant of renal RI in septic, critically ill patients suffering or not from acute kidney injury (AKI). METHODS: This prospective observational study included 96 patients. AKI was defined according to RIFLE criteria and transient or persistent AKI according to renal recovery within 3 days. RESULTS: Median renal RIs were 0.72 (0.68-0.75) in patients without AKI and 0.76 (0.72-0.80) in patients with AKI (P=0.001). RIs were 0.75 (0.72-0.79) in transient AKI and 0.77 (0.70-0.80) in persistent AKI (P=0.84). RI did not differ in patients given norepinephrine infusion and was not correlated with norepinephrine dose. RI was correlated with MAP (ρ= -0.47; P=0.002), PaO2/FiO2 ratio (ρ= -0.33; P=0.04) and age (ρ=0.35; P=0.015) only in patients without AKI. CONCLUSIONS: A poor correlation between renal RI and MAP, age, or PaO2/FiO2 ratio was found in septic and critically ill patients without AKI compared to patients with AKI. These findings suggest that determinants of RI are multiple. Renal circulatory response to sepsis estimated by Doppler ultrasonography cannot reliably be predicted simply from changes in systemic hemodynamics. As many factors influence its value, the interest in a single RI measurement at ICU admission to determine optimal MAP remains uncertain.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 2%
France 2 2%
Turkey 1 <1%
Unknown 109 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 16%
Student > Ph. D. Student 14 12%
Professor > Associate Professor 11 10%
Other 10 9%
Student > Master 9 8%
Other 28 25%
Unknown 24 21%
Readers by discipline Count As %
Medicine and Dentistry 75 66%
Engineering 2 2%
Agricultural and Biological Sciences 2 2%
Nursing and Health Professions 2 2%
Veterinary Science and Veterinary Medicine 1 <1%
Other 6 5%
Unknown 26 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2012.
All research outputs
#17,285,668
of 25,373,627 outputs
Outputs from Critical Care
#5,468
of 6,554 outputs
Outputs of similar age
#123,853
of 187,308 outputs
Outputs of similar age from Critical Care
#72
of 98 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
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