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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A transcription factor–based mechanism for mouse heterochromatin formation
|
|---|---|
| Published in |
Nature Structural & Molecular Biology, September 2012
|
| DOI | 10.1038/nsmb.2382 |
| Pubmed ID | |
| Authors |
Aydan Bulut-Karslioglu, Valentina Perrera, Manuela Scaranaro, Inti Alberto de la Rosa-Velazquez, Suzanne van de Nobelen, Nicholas Shukeir, Johannes Popow, Borbala Gerle, Susanne Opravil, Michaela Pagani, Simone Meidhof, Thomas Brabletz, Thomas Manke, Monika Lachner, Thomas Jenuwein |
| Abstract |
Heterochromatin is important for genome integrity and stabilization of gene-expression programs. We have identified the transcription factors Pax3 and Pax9 as redundant regulators of mouse heterochromatin, as they repress RNA output from major satellite repeats by associating with DNA within pericentric heterochromatin. Simultaneous depletion of Pax3 and Pax9 resulted in dramatic derepression of major satellite transcripts, persistent impairment of heterochromatic marks and defects in chromosome segregation. Genome-wide analyses of methylated histone H3 at Lys9 showed enrichment at intergenic major satellite repeats only when these sequences retained intact binding sites for Pax and other transcription factors. Additionally, bioinformatic interrogation of all histone methyltransferase Suv39h-dependent heterochromatic repeat regions in the mouse genome revealed a high concordance with the presence of transcription factor binding sites. These data define a general model in which reiterated arrangement of transcription factor binding sites within repeat sequences is an intrinsic mechanism of the formation of heterochromatin. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| Canada | 1 | 25% |
| Germany | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 333 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 2% |
| Russia | 2 | <1% |
| United States | 2 | <1% |
| Spain | 2 | <1% |
| Brazil | 2 | <1% |
| France | 1 | <1% |
| Italy | 1 | <1% |
| Czechia | 1 | <1% |
| Canada | 1 | <1% |
| Other | 5 | 2% |
| Unknown | 311 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 97 | 29% |
| Researcher | 80 | 24% |
| Student > Master | 30 | 9% |
| Student > Bachelor | 28 | 8% |
| Professor > Associate Professor | 19 | 6% |
| Other | 42 | 13% |
| Unknown | 37 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 181 | 54% |
| Biochemistry, Genetics and Molecular Biology | 89 | 27% |
| Medicine and Dentistry | 11 | 3% |
| Immunology and Microbiology | 3 | <1% |
| Computer Science | 2 | <1% |
| Other | 11 | 3% |
| Unknown | 36 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2023.
All research outputs
#2,485,602
of 25,374,647 outputs
Outputs from Nature Structural & Molecular Biology
#989
of 4,186 outputs
Outputs of similar age
#15,833
of 177,050 outputs
Outputs of similar age from Nature Structural & Molecular Biology
#6
of 52 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,186 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.5. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 177,050 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.