↓ Skip to main content

Performance of POC-CCA® in diagnosis of schistosomiasis mansoni in individuals with low parasite burden

Overview of attention for article published in Revista da Sociedade Brasileira de Medicina Tropical, June 2016
Altmetric Badge

Mentioned by

twitter
2 X users

Citations

dimensions_citation
33 Dimensions

Readers on

mendeley
87 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Performance of POC-CCA® in diagnosis of schistosomiasis mansoni in individuals with low parasite burden
Published in
Revista da Sociedade Brasileira de Medicina Tropical, June 2016
DOI 10.1590/0037-8682-0070-2016
Pubmed ID
Authors

Liliane Maria Vidal Siqueira, Flavia Fernanda Bubula Couto, Diana Taboada, Áureo Almeida de Oliveira, Nidia Francisca de Figueiredo Carneiro, Edward Oliveira, Paulo Marcos Zech Coelho, Naftale Katz

Abstract

Schistosomiasis, caused by Schistosoma mansoni, is a public health concern in Brazil. However, the most popular diagnostic method, the Kato-Katz technique, exhibits low sensitivity in low-endemicity areas. We aimed to compare the performance of an immunological assay, the point-of-care circulating cathodic antigen (POC-CCA®) test, with that of two parasitological techniques in a low-endemicity population. Our study included 141 individuals living in Estreito de Miralta, Minas Gerais, Brazil. Fecal samples were obtained from all participants and analyzed for schistosomiasis using two parasitological techniques: the Kato-Katz technique and the saline gradient technique. Additionally, POC-CCA® strips were utilized for testing urine samples. The results obtained by the different techniques were compared. Analysis of two or 24 slides using the Kato-Katz technique resulted in a positivity rate of 10.6% (15/141) or 19.1% (27/141), respectively. The saline gradient technique yielded a positivity rate of 17.0% (24/141). The prevalence according to both parasitological techniques was 24.1% (34/141). The POC-CCA® test yielded a positivity rate of 22.7% (32/141); however, the positivity rate was merely 2.1% if trace results were considered negative. The agreements observed between POC-CCA® and the parasitological techniques were good (Kappa indexes > 0.64). The POC-CCA® test was more sensitive than the two-slide Kato-Katz technique (p < 0.05) in detecting cases of S. mansoni infection when trace results were considered positive. These findings reinforce the importance of using multiple diagnostic techniques in low-endemicity areas for effective control of disease.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 2%
Unknown 85 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 15 17%
Researcher 13 15%
Student > Ph. D. Student 10 11%
Student > Bachelor 10 11%
Student > Postgraduate 8 9%
Other 15 17%
Unknown 16 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 26%
Biochemistry, Genetics and Molecular Biology 14 16%
Medicine and Dentistry 10 11%
Immunology and Microbiology 7 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Other 8 9%
Unknown 22 25%