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Performance of POC-CCA® in diagnosis of schistosomiasis mansoni in individuals with low parasite burden

Overview of attention for article published in Revista da Sociedade Brasileira de Medicina Tropical, June 2016
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Title
Performance of POC-CCA® in diagnosis of schistosomiasis mansoni in individuals with low parasite burden
Published in
Revista da Sociedade Brasileira de Medicina Tropical, June 2016
DOI 10.1590/0037-8682-0070-2016
Pubmed ID
Authors

Liliane Maria Vidal Siqueira, Flavia Fernanda Bubula Couto, Diana Taboada, Áureo Almeida de Oliveira, Nidia Francisca de Figueiredo Carneiro, Edward Oliveira, Paulo Marcos Zech Coelho, Naftale Katz

Abstract

Schistosomiasis, caused by Schistosoma mansoni, is a public health concern in Brazil. However, the most popular diagnostic method, the Kato-Katz technique, exhibits low sensitivity in low-endemicity areas. We aimed to compare the performance of an immunological assay, the point-of-care circulating cathodic antigen (POC-CCA®) test, with that of two parasitological techniques in a low-endemicity population. Our study included 141 individuals living in Estreito de Miralta, Minas Gerais, Brazil. Fecal samples were obtained from all participants and analyzed for schistosomiasis using two parasitological techniques: the Kato-Katz technique and the saline gradient technique. Additionally, POC-CCA® strips were utilized for testing urine samples. The results obtained by the different techniques were compared. Analysis of two or 24 slides using the Kato-Katz technique resulted in a positivity rate of 10.6% (15/141) or 19.1% (27/141), respectively. The saline gradient technique yielded a positivity rate of 17.0% (24/141). The prevalence according to both parasitological techniques was 24.1% (34/141). The POC-CCA® test yielded a positivity rate of 22.7% (32/141); however, the positivity rate was merely 2.1% if trace results were considered negative. The agreements observed between POC-CCA® and the parasitological techniques were good (Kappa indexes > 0.64). The POC-CCA® test was more sensitive than the two-slide Kato-Katz technique (p < 0.05) in detecting cases of S. mansoni infection when trace results were considered positive. These findings reinforce the importance of using multiple diagnostic techniques in low-endemicity areas for effective control of disease.

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The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 2%
Unknown 79 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 16 20%
Researcher 13 16%
Student > Ph. D. Student 10 12%
Student > Bachelor 9 11%
Student > Postgraduate 8 10%
Other 14 17%
Unknown 11 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 28%
Biochemistry, Genetics and Molecular Biology 14 17%
Medicine and Dentistry 10 12%
Immunology and Microbiology 7 9%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Other 7 9%
Unknown 17 21%